2. Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Neuronal Signaling
  3. DYRK CDK Tau Protein
  4. DYRK2-IN-2

DYRK2-IN-2 (Compound C17) 是一种选择性的 DYRK2 抑制剂，其 IC50 为 40.3 nM。DYRK2-IN-2 对 DYRK1A (IC50 = 1842 nM)、DYRK1B (IC50 = 1335 nM)、DYRK4 (IC50 = 1931 nM)、DYRK3 (IC50 = 112 nM) 和 CLKs (IC50 = 540-6496 NM) 的抑制活性更小。DYRK2-IN-2 抑制了 Tau 蛋白 Thr212 的磷酸化，对 HT22 细胞显示出中等程度的细胞毒性。DYRK2-IN-2 可用于抗癌研究。

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DYRK2-IN-2

DYRK2-IN-2 Chemical Structure

CAS No. : 2416195-65-6

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DYRK2-IN-2 相关抗体

Top Publications Citing Use of Products

查看 DYRK 亚型特异性产品:

查看所有亚型
DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DYRK2-IN-2 (Compound C17) is a selective inhibitor of DYRK2, with its IC50 value being 40.3 nM. The inhibitory activity of DYRK2-IN-2 on DYRK1A (IC50 = 1842 nM), DYRK1B (IC50 = 1335 nM), DYRK4 (IC50 = 1931 nM), DYRK3 (IC50 = 112 nM), and CLKs (IC50 = 540-6496 NM) is relatively low. DYRK2-IN-2 inhibits the phosphorylation of Tau protein at Thr212 and shows moderate cytotoxicity in HT22 cells. DYRK2-IN-2 can be used in cancer research[1].

IC50 & Target[1]

DYRK2

40.3 nM (IC50)

DYRK1A

1842 nM (IC50)

DYRK1B

1335 nM (IC50)

DYRK4

1931 nM (IC50)

DYRK3

112 nM (IC50)

CLK1

1128 nM (IC50)

CLK2

4290 nM (IC50)

CLK3

6496 nM (IC50)

CLK4

536.9 nM (IC50)

分子量

384.49

Formula

C21H24N2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DYRK2-IN-2 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DYRK2-IN-22416195-65-6DYRKCDKTau ProteinDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseCyclin dependent kinaseInhibitorinhibitorinhibit

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