2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. DZ-2384

DZ-2384 是一种强效的微管 (microtubule) 靶向剂。DZ-2384可提高微管救援频率，并在非分裂细胞和原代神经元中保持微管网络结构。在 Taxane 敏感和 Taxane 耐药的三阴性乳腺癌 (TNBC) 异种移植小鼠模型中，DZ-2384 与抗 CTLA-4 联用具有协同作用。DZ-2384 在成人急性淋巴细胞白血病 (ALL) 模型中表现出强大的抗肿瘤活性。DZ-2384 可用于癌症研究，例如 TNBC 和 ALL[1][2]。

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DZ-2384

DZ-2384 Chemical Structure

CAS No. : 1403850-91-8

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DZ-2384 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DZ-2384 is a potent microtubule-targeting agent. DZ-2384 increases the rescue frequency and preserves the microtubule network in nonmitotic cells and primary neurons. DZ-2384 acts synergistically with anti-CTLA-4 immunotherapy in Taxane-sensitive and Taxane-resistant xenograft murine models of triple-negative breast cancer (TNBC). DZ-2384 exhibits potent antitumor activity in adult acute lymphocytic leukemia (ALL) models. DZ-2384 can be used for cancer research, such as TNBC and ALL[1][2].

分子量

645.68

Formula

C34H36FN5O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DZ-2384 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DZ-23841403850-91-8DZ2384DZ 2384Microtubule/Tubulinmicrotubulenonmitotic cellsprimary neuronsanti-CTLA-4Taxanetriple-negative breast canceracute lymphocytic leukemiaInhibitorinhibitorinhibit

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