2. NF-κB MAPK/ERK Pathway Apoptosis
  3. NF-κB p38 MAPK Apoptosis
  4. (E/Z)-Sinigrin free base

(E/Z)-Sinigrin free base  (Synonyms: 黑芥子苷; (E/Z)-Allyl-glucosinolate free base; (E/Z)-2-Propenyl-glucosinolate free base)

目录号: HY-N2423B
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(E/Z)-Sinigrin ((E/Z)-Allyl-glucosinolate; (E/Z)-2-Propenyl-glucosinolate) free base 是一种口服有效的脂肪族硫代葡萄糖苷类抗白血病化合物。(E/Z)-Sinigrin free base 经黑芥子酶水解生成的异硫氰酸烯丙酯对 HL60 白血病细胞的 IC50 为 2.71 μM。(E/Z)-Sinigrin free base 的水解产物可进一步激活凋亡 (apoptosis) 通路、抑制 NF-κB 和 MAPK 信号通路、诱导 II 相代谢酶活性等发挥抗癌、抗炎、抗菌、抗氧化及伤口愈合活性。(E/Z)-Sinigrin free base 可用于癌症、炎症相关疾病 (如动脉粥样硬化)、感染性疾病等领域的研究。(E/Z)-Sinigrin free base 能够从 Brassica nigra (黑芥) 的种子、Brassica juncea (印度芥菜) 及西兰花、球芽甘蓝等十字花科 (Brassicaceae) 植物中天然提取得到。

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(E/Z)-Sinigrin free base

(E/Z)-Sinigrin free base Chemical Structure

CAS No. : 534-69-0

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(E/Z)-Sinigrin free base 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(E/Z)-Sinigrin ((E/Z)-Allyl-glucosinolate; (E/Z)-2-Propenyl-glucosinolate) free base is an orally active aliphatic thioglucoside anti-leukemia compound. Allyl isothiocyanate, produced by the hydrolysis of (E/Z)-sinigrin free base by myrosinase, has an IC50 of 2.71 μM against HL60 leukemia cells. The hydrolysis products of (E/Z)-sinigrin free base can further activate apoptosis pathways, inhibit NF-κB and MAPK signaling pathways, and induce phase II metabolic enzyme activity, thus exhibiting anti-cancer, anti-inflammatory, antibacterial, antioxidant, and wound healing activities. (E/Z)-Sinigrin free base can be used in research on cancer, inflammation-related diseases (such as atherosclerosis), and infectious diseases. (E/Z)-Sinigrin free base can be naturally extracted from the seeds of Brassica nigra, Brassica juncea, and other Brassicaceae plants such as broccoli and Brussels sprouts. Methyl pechueloate is a guaiane-type sesquiterpene ester compound and a potential precursor of xerantholide. It is useful in the structural elucidation and biosynthetic pathway studies of sesquiterpenoids. Methyl pechueloate can be naturally extracted from the aerial parts of Pechuel-Loeschea leibnitziae (Kuntze) O. Hoffm[1].

分子量

359.37

Formula

C10H17NO9S2
CAS 号
中文名称

黑芥子苷
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(E/Z)-Sinigrin free base 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

(E/Z)-Sinigrin534-69-0(E/Z)-Allyl-glucosinolate(E/Z)-2-Propenyl-glucosinolate黑芥子苷NF-κBp38 MAPKApoptosisNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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