2. Apoptosis PI3K/Akt/mTOR
  3. Apoptosis Akt
  4. EEF1A2-IN-1

EEFA2-IN-1 是一种强效的共价 EEF1A2 抑制剂。EEFA2-IN-1 对骨肉瘤 (OS) 细胞具有选择性抗增殖活性。EEF1A2-IN-1 通过抑制 EEF1A2 并下调 AKT 信号通路诱导细胞凋亡 (apoptosis)。EEF1A2-IN-1 在异种移植小鼠模型中抑制肿瘤生长。EEF1A2-IN-1 可用于骨肉瘤 (OS) 的研究。

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EEF1A2-IN-1

EEF1A2-IN-1 Chemical Structure

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EEF1A2-IN-1 相关抗体

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EEF1A2-IN-1 is a potent and covalen EEF1A2 inhibitor. EEF1A2-IN-1 exhibits selective antiproliferative activity against osteosarcoma (OS) cells. EEF1A2-IN-1 induces apoptosis by inhibiting EEF1A2 and downregulating the AKT signaling pathway. EEF1A2-IN-1 inhibits tumor growth in a xenograft mouse model. EEF1A2-IN-1 can be used for the research of OS[1].

体外研究
(In Vitro)

EEF1A2-IN-1 (compound 8e) (24-72 小时) 对多种细胞系表现出强效的抗增殖活性，IC50 值分别为 0.73 (143B)、2.27 (SJSA-1)、4.34 (MG63)、2.47 (MNNG/HOS)、7.25 (U2OS)、1.93 (HOS)、4.84 (A549) 和 9.59 μM (BMSC)[1]。
EEF1A2-IN-1 (96 小时-10 天) 以 EEF1A2 依赖的方式抑制 143B 细胞的集落形成，也抑制 143B 细胞、si-EEF1A2-2 细胞和 OE-EEF1A2 143B 细胞的增殖，IC50 值分别为 0.73、2.78 和 0.19 μM，表明 EEF1A2 对 OS 143B 细胞的增殖和迁移至关重要[1]。
EEF1A2-IN-1 (0-3 μM，0-24 小时) 能有效抑制 143B 细胞的迁移[1]。
EEF1A2-IN-1 (0-3 μM) 能有效抑制 143B 细胞的侵袭[1]。
EEF1A2-IN-1 (0-3 μM) 通过抑制其靶标 EEF1A2 诱导 143B 细胞凋亡，从而导致 Nogo-B 蛋白和 AKT 信号通路下调[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EEF1A2-IN-1 相关抗体:

Cell Migration Assay [1]

Cell Line: 143B cells
Concentration: 0, 0.3, 1, 3 μM
Incubation Time: 0, 24 h
Result: Revealed a significant decrease in the percentage of intercellular wound healing distance.
Inhibited the migration of 143B cells.
体内研究
(In Vivo)

EEFA2-IN-1 (20 mg/kg，腹腔注射，每日一次，持续 15 天) 在 143B 异种移植小鼠模型中显著抑制肿瘤生长，且无明显毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c nude mice (3 months old) subcutaneously injected with 143B cells[1]
Dosage: 20 mg/kg
Administration: i.p., daily for 15 days
Result: Significantly suppressed OS tumor growth, with tumor growth inhibition (TGI) rates of 30.1%.
Showed no significant change in bodyweight.
Exhibited no discernible morphological changes in the heart, liver, spleen, or kidney tissues.
分子量

311.33

Formula

C18H17NO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EEF1A2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EEF1A2-IN-1ApoptosisAktPKBProtein kinase BEEF1A2OsteosarcomaTarget identificationInhibitorinhibitorinhibit

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