2. PROTAC Neuronal Signaling Apoptosis
  3. Molecular Glues CaMK Apoptosis
  4. eEF2K degrader-2

eEF2K degrader-2 是一种靶向 eEF2K 蛋白的分子胶 (molecular glues) 降解剂。eEF2K degrader-2 能显著抑制三阴性乳腺癌 (TNBC) 细胞增殖、迁移、侵袭，并诱导凋亡 (apoptosis)。eEF2K degrader-2 无明显器官毒性或病理损伤。eEF2K degrader-2 可以用于癌症如乳腺癌的研究。

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eEF2K degrader-2

eEF2K degrader-2 Chemical Structure

CAS No. : 1044797-96-7

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eEF2K degrader-2 相关抗体

Top Publications Citing Use of Products

查看 CaMK 亚型特异性产品:

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CaMK II CaMK III/eEF-2K CAMK IV PHK Trio DCAMKL

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

eEF2K degrader-2 is a molecular glucose degrading agent that targets the eEF2K protein. eEF2K degrader-2 can significantly inhibit the proliferation, migration, invasion and induce apoptosis of triple negative breast cancer (TNBC) cells. eEF2K degrader-2 has no obvious organ toxicity or pathological damage. eEF2K degrader-2 can be used in the research of cancer such as breast cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDA-MB-231 IC50
131.2 nM
Compound: C1
Antitumor activity against human MDA-MB-231 cells assessed as inhibition of cell viability by measuring inhibition rate measured after 72 hrs by CCK-8 assay relative to control
Antitumor activity against human MDA-MB-231 cells assessed as inhibition of cell viability by measuring inhibition rate measured after 72 hrs by CCK-8 assay relative to control
[PMID: 39208364]
分子量

508.54

Formula

C27H29FN4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

eEF2K degrader-2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

eEF2K degrader-21044797-96-7Molecular GluesCaMKApoptosisCalmodulin-dependent protein kinasesCalmodulin-dependent kinaseseEF2Kmolecular gluesTNBCapoptosiscancerInhibitorinhibitorinhibit

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