2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR VEGFR Apoptosis
  4. EGFR-IN-174

EGFR-IN-174 是一种有效的 EGFR 抑制剂 (IC50 = 0.17 μM)，同时也能够抑制 VEGFR-2 (IC50 = 0.2007 μM)。EGFR-IN-174 具有强效的抗癌作用，且对正常细胞的毒性较低。EGFR-IN-174 可诱导 G2/M 期和 Pre-G1 期细胞阻滞，并显著引发细胞凋亡 (apoptosis)。EGFR-IN-174 可用于癌症相关研究，例如结直肠癌、肝细胞癌和乳腺癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

EGFR-IN-174

EGFR-IN-174 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

EGFR-IN-174 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-174 is a potent EGFR inhibitor (IC50 = 0.17 μM) and also displays VEGFR-2 inhibition (IC50 = 0.2007 μM). EGFR-IN-174 exhibits potent anticancer effects with low cytotoxicity to normal cells. EGFR-IN-174 induces G2/M and Pre-G1 phase arrest and significantly triggers apoptosis. EGFR-IN-174 can be used in cancer research, such as colorectal carcinoma, hepatocellular carcinoma, and breast cancer[1].

IC50 & Target[1]

VEGFR-2

0.2007 μM (IC50)

体外研究
(In Vitro)

EGFR-IN-174 (compound 3a) (2 天) 对 HCT-116、HepG-2 和 MCF-7 细胞系表现出强细胞毒性 (IC50 值分别为 5.58、4.82 和 11.15 μM)，同时对正常 WI-38 细胞表现出极小的细胞毒性 (IC50 = 86.26 μM)[1]。
EGFR-IN-174 (4.82-11.15 μM，72 小时) 能有效诱导 HCT-116、HepG-2 和 MCF-7 细胞的 G2/M 期和 Pre-G1 期细胞周期阻滞，并显著触发细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-174 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HCT-116, HepG-2, and MCF-7 Cells
Concentration: 5.58, 4.82, and 11.15 μM for HCT-116, HepG-2, and MCF-7 Cells, respectively
Incubation Time: 72 h
Result: Induced a significant increase in the Hep-G2 cell population in the G2/M (from 12.73 % to 34.85 %) and Pre-G1 (from 1.92 % to 11.82 %) phases.
Induced a significant increase in the HCT-116 cell population in the G2/M (from 5.45 % to 29.21 %) and Pre-G1 (from 1.91 % to 11.22 %) phases.
Significantly increased the population of MCF-7 Cells in the G2/M and Pre-G1 phases from 9.55 % and 2.14 % to 35.31 % and 15.52 %, respectively.
Reduced the proportion of cells in the G0-G1 and S phases compared to the control in Hep-G2, HCT-116, and MCF-7 cell lines.

Apoptosis Analysis[1]

Cell Line: HCT-116, HepG-2, and MCF-7 Cells
Concentration: 5.58, 4.82, and 11.15 μM for HCT-116, HepG-2, and MCF-7 Cells, respectively
Incubation Time: 72 h
Result: Induced a total apoptosis rate of 11.22 % in HCT-116 cells (early: 3.62 %; late: 6.24 %).
Induced a total apoptosis rate of 11.82 % in HepG-2 cells (early: 3.59 %; late: 6.65 %).
Induced a total apoptosis rate of 15.52 % in MCF-7 cells (early: 4.49 %; late: 8.88 %).
分子量

385.57

Formula

C16H23N3O2S3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-174 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-174EGFRVEGFRApoptosisEpidermal growth factor receptorErbB-1HER1Vascular endothelial growth factor receptorVEGFR-2antiproliferativeapoptosiscell cycle arrestHCT-116HepG-2MCF-7Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
EGFR-IN-174
目录号：
HY-178005
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z