2. Immunology/Inflammation Protein Tyrosine Kinase/RTK JAK/STAT Signaling Apoptosis
  3. COX EGFR Apoptosis
  4. EGFR-IN-190

EGFR-IN-190 (Compound 3o) 是一种同时靶向 EGFR (IC₅₀ = 0.028 μM) 和 COX-2 (IC₅₀ = 0.208 μM) 的抑制剂。EGFR-IN-190 对 MCF-7 细胞具有强效的抑制活性，且诱导了细胞凋亡 (apoptosis)。EGFR-IN-190 可用于研究乳腺癌。

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EGFR-IN-190

EGFR-IN-190 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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EGFR-IN-190 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-190 (Compound 3o) is an inhibitor that targets both EGFR (IC₅₀ = 0.028 μM) and COX-2 (IC₅₀ = 0.208 μM). EGFR-IN-190 exhibits potent inhibitory activity against MCF-7 cells and induces apoptosis (apoptosis). EGFR-IN-190 can be used for research on breast cancer[1].

IC50 & Target[1]

COX-2

0.208 μM (IC50)

EGFR

 

分子量

467.52

Formula

C17H14FN5O4S3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-190 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-190COXEGFRApoptosisCyclooxygenaseEpidermal growth factor receptorErbB-1HER1Thiadiazole derivativesdual EGFR/COX-2 inhibitorsanticancer activityapoptosis inductionmolecular dockingmolecular dynamics simulationMCF-7 cellsstructure-activity relationshipsulfonamide groupkinase inhibitionInhibitorinhibitorinhibit

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产品名称：
EGFR-IN-190
目录号：
HY-180541
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