2. PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK JAK/STAT Signaling Apoptosis
  3. Akt EGFR Apoptosis Necroptosis Caspase Bcl-2 Family MDM-2/p53
  4. EGFR-IN-191

EGFR-IN-191 是一种靶向 EGFR 和 AKT 的抗肿瘤剂。EGFR-IN-191 可通过诱导肿瘤细胞 DNA 损伤、凋亡 (apoptosis)、细胞周期阻滞及抑制 PI3K/AKT-EGFR 信号通路发挥抗肿瘤的活性。EGFR-IN-191 可用于三阴性乳腺癌等肿瘤的研究。

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EGFR-IN-191

EGFR-IN-191 Chemical Structure

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EGFR-IN-191 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-191 is an anti-tumor agent targeting both EGFR and AKT. EGFR-IN-191 exerts its anti-tumor activity by inducing DNA damage, apoptosis, cell cycle arrest, and inhibition of the PI3K/AKT-EGFR signaling pathway in tumor cells. EGFR-IN-191 can be used in the study of tumors such as triple-negative breast cancer[1].

体外研究
(In Vitro)

EGFR-IN-191 (Compound 2J) (0-20 μM；48 小时) 可抑制 MDA-MB-231、MCF-7 和 Hs 578Bst 细胞的增殖，其 IC50 值分别为 6.89 μM、7.79 μM 和 10.19 μM[1]。
EGFR-IN-191 (0-20 μM；0-48 小时) 可诱导 MDA-MB-231 细胞凋亡、细胞周期阻滞、DNA 损伤以及降低细胞的线粒体膜电位[1]。
EGFR-IN-191 (7-14.0 μM) 可下调 MDA-MB-231 细胞中 EGFR、p-EGFR 和 p-AKT 的蛋白表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-191 相关抗体:

Real Time qPCR[1]

Cell Line: MDA-MB-231
Concentration: 7.0, 10.5 and 14.0 μM
Incubation Time: 24 h
Result: Upregulated mRNA expression of Bax, BRCA1, CDKN1A, Caspase-3, PIK3CA, Mcl-1.
Slightly downregulated Bcl-2 and p53.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231
Concentration: 7.0, 10.5 and 14.0 μM
Incubation Time: 24 h
Result: Increased sub-G₀/G₁ cell accumulation dose-dependently (15.01% at 7.0 μM, 23.16% at 10.5 μM, 32.19% at 14.0 μM vs. 11.11±0.51% in control)
Induced G₂/M phase arrest (22.36% at 10.5 μM).

Apoptosis Analysis[1]

Cell Line: MDA-MB-231
Concentration: 7.0, 10.5 and 14.0 μM
Incubation Time: 24 h
Result: Increased total apoptotic cells (early + late) to 8.44% at 7.0 μM, 22.84% at 10.5 μM, and 40.83% at 14.0 μM.
Increased necrotic cells to 9.36% at 14.0 μM.
分子量

561.62

Formula

C32H35NO8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-191 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-191AktEGFRApoptosisNecroptosisCaspaseBcl-2 FamilyMDM-2/p53PKBProtein kinase BEpidermal growth factor receptorErbB-1HER1MCF-7triple-negative breast cancer cellsHs 578BstMDA-MB-231PI3K/AKT pathwayDNA damageapoptosisG2/M phase arrestInhibitorinhibitorinhibit

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