2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR-IN-194

EGFR-IN-194 是一种强效的 EGFR 酪氨酸激酶抑制剂，对人 EGFR 的 IC50 值为 54.3 nM。EGFR-IN-194 可诱导细胞凋亡 (apoptosis)、抑制癌细胞迁移、选择性促进癌细胞侵袭，并在多种癌细胞系中表现出抗增殖作用。EGFR-IN-194 可用于前列腺腺癌、非小细胞肺癌、乳腺癌、慢性粒细胞白血病的相关研究。

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EGFR-IN-194

EGFR-IN-194 Chemical Structure

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EGFR-IN-194 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-194 is a potent EGFR tyrosine kinase inhibitor with an IC50 of 54.3 nM against human EGFR. EGFR-IN-194 induces apoptosis, inhibits migration in cancer cells, selectively promotes invasion in cancer cells, and exhibits antiproliferative effects across multiple cancer cell lines. EGFR-IN-194 can be used for the research of prostate adenocarcinoma, non-small cell lung carcinoma, breast carcinoma, chronic myeloid leukemia[1].

IC50 & Target[1]

EGFR

54.3 nM (IC50)

体外研究
(In Vitro)

EGFR-IN-194 (compound 24) (1-100 μM；48 小时) 可强效抑制 PC-3、A549、MCF-7 和 K562 癌细胞的增殖，其 IC50 值分别为 3.18 μM、9.69 μM、43.51 μM 和 71.18 μM，但对 NIH3T3 非癌细胞无明显影响[1]。
EGFR-IN-194 (5 μM；作用 PC-3 细胞 24 h；10 μM；作用 A549 细胞 24 h) 可诱导 PC-3 和 A549 细胞发生线粒体去极化，并可诱导 PC-3 和 A549 细胞发生细胞凋亡[1]。
EGFR-IN-194 (5 μM；PC-3 细胞处理时长可达 48 h；10 μM；A549 细胞处理时长可达 48 h) 可抑制 PC-3 和 A549 细胞的迁移，伤口闭合程度降低的结果可证明这一点[1]。
EGFR-IN-194 (约 18 h) 可促进 PC-3 细胞的侵袭并抑制 A549 细胞的侵袭[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-194 相关抗体:

Cell Proliferation Assay[1]

Cell Line: K562, PC-3, MCF-7, A549, NIH3T3
Concentration: 1-100 μM
Incubation Time: 48 h
Result: Inhibited proliferation of K562 cells with an IC50 of 71.18 μM; inhibited proliferation of PC-3 cells with an IC50 of 3.18 μM; inhibited proliferation of MCF-7 cells with an IC50 of 43.51 μM; inhibited proliferation of A549 cells with an IC50 of 9.69 μM; showed minimal cytotoxicity toward NIH3T3 cells with an IC50 > 100 μM.

Apoptosis Analysis[1]

Cell Line: PC-3, A549
Concentration: 5 μM (PC-3); 10 μM (A549)
Incubation Time: 24 h (PC-3); 24 h (A549)
Result: Induced early and late apoptosis in PC-3 cells, characterized by condensed/fragmented nuclei; induced intense nuclear fragmentation and increased late apoptotic cells in A549 cells.

Cell Migration Assay [1]

Cell Line: PC-3, A549
Concentration: 5 μM (PC-3); 10 μM (A549)
Incubation Time: 48 h
Result: Moderately inhibited PC-3 migration at 24 h and significantly reduced wound closure at 48 h; severely inhibited A549 migration at 48 h compared to controls.
分子量

504.62

Formula

C28H29FN4O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-194 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-194EGFRApoptosisEpidermal growth factor receptorErbB-1HER1hEGFRPC-3prostate adenocarcinomaapoptosistyrosine kinaseMCF-7A549NIH3T3K562human epidermal growth factor receptorInhibitorinhibitorinhibit

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HY-181166
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