2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. EGIS-8332

EGIS-8332 是一种非竞争性的 AMPA 受体拮抗剂。EGIS-8332 可抑制大鼠小脑浦肯野细胞中的 AMPA 电流，并抑制端脑神经元原代培养物中由 AMPA 和 Quisqualate 诱导的兴奋性毒性 (IC50 值为 5.1-9.0 μM)。EGIS-8332 具有抗惊厥和神经保护作用。EGIS-8332 可用于神经系统疾病的研究。

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EGIS-8332

EGIS-8332 Chemical Structure

CAS No. : 220725-87-1

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EGIS-8332 相关抗体

Top Publications Citing Use of Products

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AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGIS-8332 is a non-competitive AMPA receptor antagonist. EGIS-8332 inhibits AMPA currents in rat cerebellar Purkinje cells and inhibited the AMPA- and Quisqualate-induced excitotoxicity in primary cultures of telencephalon neurons (IC50 = 5.1-9.0 μM). EGIS-8332 exhibits anticonvulsant and neuroprotective effects. EGIS-8332 can be used for the research of neurological disease[1].

IC50 & Target[1]

AMPA Receptor

 

体内研究
(In Vivo)

EGIS-8332 (腹腔注射) 在小鼠的最大电休克、声音和化学诱导的癫痫发作中表现出抗惊厥作用 (ED50 值为 1.4-14.0 mg kg)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

362.38

Formula

C20H18N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGIS-8332 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGIS-8332220725-87-1EGIS8332EGIS 8332iGluRIonotropic glutamate receptorsAMPAPurkinjeQuisqualateexcitotoxicityanticonvulsantneuroprotectivestorkeInhibitorinhibitorinhibit

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目录号：
HY-114975
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