2. Metabolic Enzyme/Protease Epigenetics
  3. HIF/HIF Prolyl-Hydroxylase Epigenetic Reader Domain
  4. eIF3e-IN-1

eIF3e-IN-1 (Compound 209) 是一种 elF3e 抑制剂，其 EC50 为 18.3 μM。eIF3e-IN-1 显著减弱了缺氧诱导的 HIF1α 蛋白积累，抑制急性翻译缺氧反应。eIF3e-IN-1 显著抑制了 ATF4 蛋白表达。eIF3e-IN-1 可用于癌症研究，如乳腺癌。

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eIF3e-IN-1

eIF3e-IN-1 Chemical Structure

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eIF3e-IN-1 相关抗体

Top Publications Citing Use of Products

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

eIF3e-IN-1 (Compound 209) is an elF3e inhibitor with an EC50 of 18.3 μM. eIF3e-IN-1 significantly reduces the accumulation of HIF1α protein induced by hypoxia and inhibits the acute translation hypoxia response. eIF3e-IN-1 significantly inhibits the expression of ATF4 protein. eIF3e-IN-1 can be used in cancer research, such as in breast cancer studies[1].

分子量

305.29

Formula

C16H11N5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

eIF3e-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

eIF3e-IN-1HIF/HIF Prolyl-HydroxylaseEpigenetic Reader DomainHypoxia-inducible factorsHIFsHIF-PHhypoxiaselective translationribosome profilingsmall molecule inhibitorbreast cancerstress responsemetastasisHIF1αATF4Inhibitorinhibitorinhibit

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