2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Ensifentrine tosylate

Ensifentrine (RPL-554) tosylate 是一种吸入式的 PDE3 和 PDE4 双重抑制剂，IC50 分别为 0.4 nM 和 1479 nM。Ensifentrine tosylate 通过阻断 PDE3 和 PDE4 酶，增加肺细胞中的环磷酸腺苷 (cAMP) 和环磷酸鸟苷 (cGMP) 水平，扩张支气管，并抑制炎症细胞的活化和迁移。Ensifentrine tosylate 可用于慢性阻塞性肺疾病 (COPD) 的研究。

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Ensifentrine tosylate

Ensifentrine tosylate Chemical Structure

CAS No. : 3098314-20-3

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Ensifentrine tosylate 的其他形式现货产品:

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Ensifentrine tosylate 相关抗体

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

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  • 参考文献

生物活性

Ensifentrine (RPL-554) tosylate is an inhaled dual inhibitor of PDE3 and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively. Ensifentrine tosylate blocks PDE3 and PDE4 enzymes, thereby increasing the levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in lung cells, dilating the bronchi, and inhibiting the activation and migration of inflammatory cells. Ensifentrine tosylate can be used in the research of chronic obstructive pulmonary disease (COPD)[1][2][3].

IC50 & Target[1]

PDE3

0.4 nM (IC50)

PDE4

1479 nM (IC50)

分子量

649.76

Formula

C33H39N5O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ensifentrine tosylate 相关分类

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Keywords:

Ensifentrine3098314-20-3RPL-554RPL554RPL 554Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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