Enviroxime (Synonyms: LY122772)

目录号: HY-106312A 一键复制产品信息纯度: 98.0%: Data Sheet SDS COA 产品使用指南
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技术支持

Enviroxime (LY122772) 是一种抗病毒化合物，可抑制鼻病毒和肠道病毒的复制。 Enviroxime 通过靶向病毒 3A 编码区来阻断正链病毒 RNA 的复制。 Enviroxime 可成为研究 3A 蛋白天然功能的有用工具。

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Enviroxime Chemical Structure

CAS No. : 72301-79-2

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规格	价格	是否有货
1 mg	￥1800	In-stock
5 mg	￥4211	In-stock
10 mg		询价
50 mg		询价

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Other Forms of Enviroxime:

Viroxime 询价

Enviroxime 相关产品

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生物活性
纯度 & 产品资料
参考文献

生物活性

Enviroxime (LY122772) is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses. Enviroxime blocks the replication of plus-strand viral RNA by targeting the viral 3A coding region. Enviroxime can be a useful tool for investigating the natural function of the 3A protein^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
BSC-1	IC₅₀	0.02 μg/mL Compound: 1	Antiviral activity against Poliovirus (PV-1) using plaque reduction assay using BSC1 cells Antiviral activity against Poliovirus (PV-1) using plaque reduction assay using BSC1 cells	[PMID: 9341923]
CV-1	ED₅₀	275 μg/mL Compound: Enviroxime2	Compound was evaluated for chemotherapeutic index in CV-1 cells (chemotherapeutic index=50% cytotoxic dose/50% effective dose) Compound was evaluated for chemotherapeutic index in CV-1 cells (chemotherapeutic index=50% cytotoxic dose/50% effective dose)	[PMID: 3005577]
CV-1	ED₅₀	8.8 μg/mL Compound: Enviroxime2	Antiviral activity against poliovirus type 1 in CV-1 cells Antiviral activity against poliovirus type 1 in CV-1 cells	[PMID: 3005577]
H1-HeLa	CC₅₀	16.76 μM Compound: Enviroxime	Cytotoxicity against human H1-HeLa cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human H1-HeLa cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 39032404]
H1-HeLa	CC₅₀	9.9 μM Compound: Enviroxime	Cytotoxicity against human H1-HeLa cells infected with 1 MOI human rhinovirus 14 pretreated with compound for 1 hr followed by viral infection measured by MTT assay Cytotoxicity against human H1-HeLa cells infected with 1 MOI human rhinovirus 14 pretreated with compound for 1 hr followed by viral infection measured by MTT assay	[PMID: 38389877]
H1-HeLa	IC₅₀	41 μM Compound: Enviroxime	Cytotoxicity against human H1-HeLa cells transfected with EV71 replicon measured after 8 hrs by MTT assay Cytotoxicity against human H1-HeLa cells transfected with EV71 replicon measured after 8 hrs by MTT assay	[PMID: 38389877]
HeLa	ED₅₀	5.1 μg/mL Compound: Enviroxime2	Antiviral activity against rhinovirus type 10 in Hela cells Antiviral activity against rhinovirus type 10 in Hela cells	[PMID: 3005577]
HeLa	IC₅₀	0.04 μg/mL Compound: 1	Antiviral activity against Rhinovirus (RV-14) in HeLa cells using CPE/XTT assay Antiviral activity against Rhinovirus (RV-14) in HeLa cells using CPE/XTT assay	[PMID: 9341923]
HeLa	IC₅₀	0.04 μg/mL Compound: 1	Antiviral activity against Rhinovirus (RV-16) in HeLa cells using CPE/XTT assay Antiviral activity against Rhinovirus (RV-16) in HeLa cells using CPE/XTT assay	[PMID: 9341923]
HeLa	IC₅₀	0.05 μg/mL Compound: 1	Antiviral activity against Coxsackie virus (CoxA21) in HeLa cells using CPE/XTT assay Antiviral activity against Coxsackie virus (CoxA21) in HeLa cells using CPE/XTT assay	[PMID: 9341923]
HeLa	IC₅₀	0.06 μg/mL Compound: 1	Antiviral activity against Poliovirus (PV-1) in HeLa cells using CPE/XTT assay Antiviral activity against Poliovirus (PV-1) in HeLa cells using CPE/XTT assay	[PMID: 9341923]
HeLa	IC₅₀	0.07 μg/mL Compound: 1	Antiviral activity against Rhinovirus (RV-2) in HeLa cells using CPE/XTT assay Antiviral activity against Rhinovirus (RV-2) in HeLa cells using CPE/XTT assay	[PMID: 9341923]
Huh-7	CC₅₀	25 μM Compound: 93	Cytotoxicity against human Huh-7 cells Cytotoxicity against human Huh-7 cells	[PMID: 33539089]
KB	CC₅₀	2 μg/mL Compound: Enviroxime	Cellular toxicity in KB cells Cellular toxicity in KB cells	[PMID: 12852746]
RD	CC₅₀	1.5 μM Compound: Enviroxime	Cytotoxicity against human RD cells by neutral red uptake assay Cytotoxicity against human RD cells by neutral red uptake assay	[PMID: 33031923]
RD	CC₅₀	10 μM Compound: Enviroxime	Cytotoxicity against human RD cells assessed as reduction in cell viability by visual analysis Cytotoxicity against human RD cells assessed as reduction in cell viability by visual analysis	[PMID: 37120998]
RD	CC₅₀	28 μM Compound: Enviroxime	Cytotoxicity against human RD cells infected with Enterovirus A71 assessed as reduction in cell viability measured by CCK-8 assay Cytotoxicity against human RD cells infected with Enterovirus A71 assessed as reduction in cell viability measured by CCK-8 assay	[PMID: 32619885]
RD	CC₅₀	36.4 μM Compound: Enviroxime	Cytotoxicity against human RD cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human RD cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 39032404]
RD	CC₅₀	4.2 μM Compound: Enviroxime	Cytotoxicity against human RD cells by microscopic based visual inspection method Cytotoxicity against human RD cells by microscopic based visual inspection method	[PMID: 33031923]
RD	CC₅₀	5.5 μM Compound: Enviroxime	Cytotoxicity against human RD cells assessed as reduction in cell viability by neutral red dye based spectrophotometric analysis Cytotoxicity against human RD cells assessed as reduction in cell viability by neutral red dye based spectrophotometric analysis	[PMID: 37120998]
RD	CC₅₀	> 223.21 μM Compound: 1	Cytotoxicity against human RD cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay Cytotoxicity against human RD cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay	[PMID: 26885567]
RD	EC₅₀	0.24 μM Compound: 1	Antiviral activity against Enterovirus 71 infected in human RD cells after 24 to 36 hrs by MTS-based CPE reduction assay Antiviral activity against Enterovirus 71 infected in human RD cells after 24 to 36 hrs by MTS-based CPE reduction assay	[PMID: 26885567]
Vero	CC₅₀	> 100 μM Compound: 2	Cytotoxicity against African green monkey Vero cells after 3 days by spectrophotometry based MTS/PMS assay Cytotoxicity against African green monkey Vero cells after 3 days by spectrophotometry based MTS/PMS assay	[PMID: 22305341]
Vero	CC₅₀	> 100 μM Compound: 59	Cytotoxicity against african green monkey Vero cells after 3 days by MTS assay Cytotoxicity against african green monkey Vero cells after 3 days by MTS assay	[PMID: 19924996]
Vero	CC₅₀	> 223.21 μM Compound: 1	Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay	[PMID: 26885567]
Vero	EC₅₀	0.026 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.027 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 41 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 41 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.027 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 63 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 63 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.028 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 39 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 39 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.029 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 29 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 29 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.033 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 85 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 85 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.038 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 9 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 9 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.04 μM Compound: Enviroxime	Antiviral activity against Human poliovirus 3 strain Sabin infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human poliovirus 3 strain Sabin infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.042 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 15 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 15 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.06 μM Compound: Enviroxime	Antiviral activity against Human poliovirus 2 Sabin infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human poliovirus 2 Sabin infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.1 μM Compound: 1	Antiviral activity against Human coxsackievirus B6 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay Antiviral activity against Human coxsackievirus B6 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay	[PMID: 26885567]
Vero	EC₅₀	0.1 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 89 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 89 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.11 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 14 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 14 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.11 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 42 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 42 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.11 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 70 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 70 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.12 μM Compound: 1	Antiviral activity against Human coxsackievirus B5 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay Antiviral activity against Human coxsackievirus B5 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay	[PMID: 26885567]
Vero	EC₅₀	0.12 μM Compound: Enviroxime	Antiviral activity against Human coxsackievirus A16 (strain G-10) A16 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human coxsackievirus A16 (strain G-10) A16 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.14 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 86 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 86 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.15 μM Compound: 1	Antiviral activity against Human coxsackievirus B2 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay Antiviral activity against Human coxsackievirus B2 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay	[PMID: 26885567]
Vero	EC₅₀	0.15 μM Compound: 1	Antiviral activity against Human enterovirus 71 infected in monkey African green Vero cells by MTS-based CPE reduction assay Antiviral activity against Human enterovirus 71 infected in monkey African green Vero cells by MTS-based CPE reduction assay	[PMID: 26885567]
Vero	EC₅₀	0.15 μM Compound: Enviroxime	Antiviral activity against Human enterovirus 71 (strain BRCR) infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human enterovirus 71 (strain BRCR) infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.19 μM Compound: Enviroxime	Antiviral activity against Human poliovirus 1 strain Sabin infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human poliovirus 1 strain Sabin infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.25 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 45 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 45 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.48 μM Compound: Enviroxime	Antiviral activity against Human coxsackievirus A21 (strain Coe) infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human coxsackievirus A21 (strain Coe) infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.5 μM Compound: Enviroxime	Antiviral activity against Human coxsackievirus B3 harboring wild type nonstructural protein 3A infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay Antiviral activity against Human coxsackievirus B3 harboring wild type nonstructural protein 3A infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay	[PMID: 19237651]
Vero	EC₅₀	0.7 μM Compound: 2	Antiviral activity against Coxsackievirus B3 Nancy infected in african green monkey Vero cells assessed as inhibition of virus-induced cell death after 3 days by spectrophotometry based MTS/PMS assay Antiviral activity against Coxsackievirus B3 Nancy infected in african green monkey Vero cells assessed as inhibition of virus-induced cell death after 3 days by spectrophotometry based MTS/PMS assay	[PMID: 22305341]
Vero	EC₅₀	0.7 μM Compound: 59	Antiviral activity against Coxsackievirus B3 infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect after 3 days by MTS assay Antiviral activity against Coxsackievirus B3 infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect after 3 days by MTS assay	[PMID: 19924996]
Vero	EC₅₀	0.7 μM Compound: Enviroxime	Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A I8T mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A I8T mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay	[PMID: 19237651]
Vero	EC₅₀	0.72 μM Compound: Enviroxime	Antiviral activity against Human rhinovirus 72 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Human rhinovirus 72 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	0.75 μM Compound: 1	Antiviral activity against Human coxsackievirus B1 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay Antiviral activity against Human coxsackievirus B1 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay	[PMID: 26885567]
Vero	EC₅₀	1.3 μM Compound: 2	Antiviral activity against drug-resistant Coxsackievirus B3 Nancy infected in african green monkey Vero cells assessed as inhibition of virus-induced cell death after 3 days by spectrophotometry based MTS/PMS assay Antiviral activity against drug-resistant Coxsackievirus B3 Nancy infected in african green monkey Vero cells assessed as inhibition of virus-induced cell death after 3 days by spectrophotometry based MTS/PMS assay	[PMID: 22305341]
Vero	EC₅₀	1.5 μM Compound: Enviroxime	Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A V45A mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A V45A mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay	[PMID: 19237651]
Vero	EC₅₀	1.7 μM Compound: Enviroxime	Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A H57Y mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A H57Y mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay	[PMID: 19237651]
Vero	EC₅₀	1.8 μM Compound: Enviroxime	Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A I54F mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A I54F mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay	[PMID: 19237651]
Vero	EC₅₀	1.9 μM Compound: Enviroxime	Antiviral activity against Coxsackievirus B3 (strain Nancy) infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay Antiviral activity against Coxsackievirus B3 (strain Nancy) infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay	[PMID: 19237651]
Vero	EC₅₀	2.48 μM Compound: 1	Antiviral activity against Human coxsackievirus B3 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay Antiviral activity against Human coxsackievirus B3 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay	[PMID: 26885567]
Vero	EC₅₀	> 186 μM Compound: 1	Antiviral activity against Human coxsackievirus B4 infected in african green monkey Vero cells by after 24 to 36 hrs MTS-based CPE reduction assay Antiviral activity against Human coxsackievirus B4 infected in african green monkey Vero cells by after 24 to 36 hrs MTS-based CPE reduction assay	[PMID: 26885567]

分子量

358.41

Formula

C₁₇H₁₈N₄O₃S

CAS 号

72301-79-2

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

细胞实验：

DMSO 中的溶解度 : ≥ 50 mg/mL (139.51 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7901 mL	13.9505 mL	27.9010 mL
5 mM	0.5580 mL	2.7901 mL	5.5802 mL
10 mM	0.2790 mL	1.3951 mL	2.7901 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (3.49 mM); 澄清溶液

此方案可获得 ≥ 1.25 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (3.49 mM); 澄清溶液

此方案可获得 ≥ 1.25 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (3.49 mM); 澄清溶液

此方案可获得 ≥ 1.25 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 98.0%

选择批次：

Data Sheet (622 KB) SDS (252 KB)

COA (289 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Heinz BA, et al. The antiviral compound enviroxime targets the 3A coding region of rhinovirus and poliovirus. J Virol. 1995 Jul;69(7):4189-97. [Content Brief]

Enviroxime 相关分类

Infection

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7901 mL	13.9505 mL	27.9010 mL	69.7525 mL
	5 mM	0.5580 mL	2.7901 mL	5.5802 mL	13.9505 mL
	10 mM	0.2790 mL	1.3951 mL	2.7901 mL	6.9753 mL
	15 mM	0.1860 mL	0.9300 mL	1.8601 mL	4.6502 mL
	20 mM	0.1395 mL	0.6975 mL	1.3951 mL	3.4876 mL
	25 mM	0.1116 mL	0.5580 mL	1.1160 mL	2.7901 mL
	30 mM	0.0930 mL	0.4650 mL	0.9300 mL	2.3251 mL
	40 mM	0.0698 mL	0.3488 mL	0.6975 mL	1.7438 mL
	50 mM	0.0558 mL	0.2790 mL	0.5580 mL	1.3951 mL
	60 mM	0.0465 mL	0.2325 mL	0.4650 mL	1.1625 mL
	80 mM	0.0349 mL	0.1744 mL	0.3488 mL	0.8719 mL
	100 mM	0.0279 mL	0.1395 mL	0.2790 mL	0.6975 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enviroxime72301-79-2LY122772LY 122772LY-122772EnterovirusRhinovirusHRVHRVsHEVHEVsInhibitorinhibitorinhibit

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Enviroxime (Synonyms: LY122772)

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Enviroxime (Synonyms: LY122772)

Customer Review

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