2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. EP4 receptor agonist 3 prodrug

EP4 receptor agonist 3 prodrug (Compound 9) 是一种 EP4 受体激动剂 (Compound 1a) 的前药。EP4 receptor agonist 3 prodrug 本身对 EP4 受体无激动活性，需在肠道内被肠道碱性磷酸酶 (IAP) 特异性水解后释放出活性分子，在肠道局部发挥 EP4 受体激动作用。EP4 receptor agonist 3 prodrug 具有结肠靶向性，显著缓解了小鼠结肠炎。

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EP4 receptor agonist 3 prodrug

EP4 receptor agonist 3 prodrug Chemical Structure

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EP4 receptor agonist 3 prodrug 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EP4 receptor agonist 3 prodrug (Compound 9) is a prodrug of EP4 receptor agonist (Compound 1a). EP4 receptor agonist 3 prodrug itself has no agonistic activity on the EP4 receptor and needs to be specifically hydrolyzed by intestinal alkaline phosphatase (IAP) in the intestine to release the active molecule, which then exerts the EP4 receptor agonistic effect locally in the intestine. EP4 receptor agonist 3 prodrug has colonic targeting properties and significantly alleviates colitis in mice[1].

IC50 & Target[1]

EP4

 

分子量

503.47

Formula

C23H32F2NO7P
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EP4 receptor agonist 3 prodrug 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EP4 receptor agonist 3 prodrugProstaglandin ReceptorEP4 receptor agonistProdrugGI-centricInflammatory bowel diseaseUlcerative colitisIntestinal alkaline phosphatase (IAP)DSS mouse modelMethylene phosphateTargeted deliveryInhibitorinhibitorinhibit

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产品名称：
EP4 receptor agonist 3 prodrug
目录号：
HY-179379
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