2. Epigenetics Apoptosis
  3. Histone Methyltransferase Apoptosis
  4. EPZ004777 formate

EPZ004777 formate 是一种有效的选择性 DOT1L 抑制剂，IC50 为 0.4 nM。EPZ004777 formate 降低 H3K79me2 和 H3K79me1 水平，显著下调 HOXA9 和 MEIS1 表达。EPZ004777 formate 选择性抑制 MLL 重排细胞的增殖，促进白血病细胞分化后再凋亡 (apoptosis)。EPZ004777 formate 可用于研究白血病。

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EPZ004777 formate

EPZ004777 formate Chemical Structure

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EPZ004777 formate 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EPZ004777 formate is an effective and selective DOT1L inhibitor, with IC50 being 0.4 nM. EPZ004777 formate reduces the levels of H3K79me2 and H3K79me1, significantly down-regulating the expression of HOXA9 and MEIS1. EPZ004777 formate selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis (apoptosis) of leukemia cells. EPZ004777 formate can be used for the study of leukemia[1][2][3].

IC50 & Target[1]

DOT1L

0.4 nM ()

分子量

585.70

Formula

C29H43N7O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EPZ004777 formate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EPZ004777 formateHistone MethyltransferaseApoptosisDOT1LEPZ004777MLLLeukemiaH3K79 methylationHistone methyltransferase inhibitorTargeted therapyGene expressionIn vivo modelInhibitorinhibitorinhibit

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