2. PROTAC Vitamin D Related/Nuclear Receptor Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. PROTACs Estrogen Receptor/ERR Reactive Oxygen Species (ROS) Apoptosis
  4. ERB-2

ERB-2 是一种选择性的 ERβ PROTAC 降解剂。ERB-2 解除 ERβ 对 ROS 的抑制作用，导致 ROS 积累、线粒体损伤，最终引发细胞凋亡 (apoptosis)。ERB-2 在 NCI-H1975OR 肿瘤的裸鼠模型显著抑制肿瘤生长。ERB-2 可用于研究非小细胞肺癌。
(粉色: Estrogen Receptor/ERR 配体 (HY-180851)；蓝色: VHL 配体 (HY-112078)；黑色: 连接子 (HY-141209))。

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ERB-2

ERB-2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

ERB-2 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ERB-2 is a selective ERβ PROTAC degrader. ERB-2 removes the inhibitory effect of ERβ on ROS, leading to the accumulation of ROS, mitochondrial damage, and ultimately triggering cell apoptosis (apoptosis). ERB-2 significantly inhibits tumor growth in the nude mouse model of NCI-H1975OR tumors. ERB-2 can be used for the study of non-small cell lung cancer[1]. (Pink: Estrogen Receptor/ERR ligand (HY-180851); Blue: VHL ligand (HY-112078); Black: linker (HY-141209)).

IC50 & Target[1]

ERβ

 

VHL

 

分子量

886.02

Formula

C46H55N5O11S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ERB-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERB-2ERB2ERB 2PROTACsEstrogen Receptor/ERRReactive Oxygen Species (ROS)ApoptosisEstrogen receptor betaPROTACOsimertinib resistanceNon-small cell lung cancerProtein degradationMolecular dynamicsROS accumulationXenograft modelInhibitorinhibitorinhibit

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目录号：
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