2. Autophagy Apoptosis
  3. Autophagy Apoptosis
  4. Erythrabyssin II

Erythrabyssin II (EL-19) 是一种强效的晚期自噬 (autophagy) 抑制剂，可阻断自噬体与溶酶体的融合。Erythrabyssin II 可导致自噬底物的积累，并且不会损害溶酶体的 pH 值或溶酶体酶活性。Erythrabyssin II 可抑制卵巢癌类器官的活性并诱导细胞凋亡 (apoptosis)。Erythrabyssin II 可用于卵巢癌的研究。

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Erythrabyssin II

Erythrabyssin II Chemical Structure

CAS No. : 77263-06-0

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Erythrabyssin II 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Erythrabyssin II (EL-19) is a potent late-stage autophagy inhibitor that blocks the fusion of autophagosome and lysosome. Erythrabyssin II leads to the accumulation of autophagic substrates and does not impair lysosomal pH or lysosomal enzyme activity. Erythrabyssin II suppresses ovarian cancer organoid activity and induces apoptosis. Erythrabyssin II can be used for the study of ovarian cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
ARPE-19 GI50
> 100 μM
Compound: 2
Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 44 hrs by AlamarBlue reagent based fluorescence assay
Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 44 hrs by AlamarBlue reagent based fluorescence assay
[PMID: 36938984]
Breast carcinoma cell IC50
2.9 μg/mL
Compound: 53
Cytotoxicity against human Breast carcinoma cell assessed as reduction in cell viability by colorimetric assay
Cytotoxicity against human Breast carcinoma cell assessed as reduction in cell viability by colorimetric assay
[PMID: 28189086]
KB IC50
5.1 μg/mL
Compound: 53
Cytotoxicity against human KB cells assessed as reduction in cell viability by colorimetric assay
Cytotoxicity against human KB cells assessed as reduction in cell viability by colorimetric assay
[PMID: 28189086]
MCF7 IC50
> 30 μM
Compound: 14
Cytotoxicity against human MCF7 cells by WST-1 assay
Cytotoxicity against human MCF7 cells by WST-1 assay
[PMID: 19836230]
MCF7 IC50
> 30 μM
Compound: 14
Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
[PMID: 19836230]
MCF7 IC50
> 30 μM
Compound: 14
Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay
Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay
[PMID: 19836230]
MDA-MB-231 IC50
> 30 μM
Compound: 14
Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
[PMID: 19836230]
分子量

392.49

Formula

C25H28O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Erythrabyssin II 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Erythrabyssin II77263-06-0AutophagyApoptosislate-stage autophagy inhibitorovarian cancerapoptosisInhibitorinhibitorinhibit

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