2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Opioid Receptor Cholinesterase (ChE) Drug Metabolite nAChR
  4. Eseroline

Eseroline 是一种强效的 μ 阿片受体 (μ-opioid receptor) 激动剂，是 Physostigmine (HY-N6608) 的水解代谢产物。Eseroline 是一种具有选择性的和竞争性的 AChE 抑制剂，其对于 AChE 和 BuChE 的 Ki 分别为 0.1 μM 和 200 μM。Eseroline 具有烟碱型乙酰胆碱受体变构增强配体 (nAChR-APL) 活性，即不激活受体，但显著增强 Ach 引发的 nAChR 信号传导。Eseroline 具有神经毒性，导致细胞膜损伤 (LDH 泄漏) 和能量代谢崩溃 (ATP 耗竭)。Eseroline 可用于研究阿尔茨海默病。

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Eseroline

Eseroline Chemical Structure

CAS No. : 469-22-7

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Other Forms of Eseroline:

Eseroline 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

查看所有亚型
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Eseroline is a potent μ-opioid receptor agonist, which is the hydrolytic metabolite of Physostigmine (HY-N6608). Eseroline is a selective and competitive acetylcholinesterase (AChE) inhibitor, with its Ki values for AChE and BuChE being 0.1 μM and 200 μM respectively. Eseroline has nicotinic acetylcholine receptor allosteric enhancing ligand (nAChR-APL) activity, meaning it does not activate the receptor but significantly enhances the signal transduction of Ach triggered by the receptor. Eseroline is neurotoxic, causing cell membrane damage (LDH leakage) and energy metabolism collapse (ATP depletion). Eseroline can be used for the study of Alzheimer's disease[1][2][3].

IC50 & Target[1]

μ Opioid Receptor/MOR

 

AChE

0.1 μM (IC50)

分子量

218.29

Formula

C13H18N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Eseroline 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eseroline469-22-7Opioid ReceptorCholinesterase (ChE)Drug MetabolitenAChRNicotinic acetylcholine receptorsAcetylcholinesteraseAlzheimer's Diseasegalantaminemorphinannicotinic acetylcholine receptoropioidrepurposingallosteric potentiating ligand (APL)Inhibitorinhibitorinhibit

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