2. NF-κB MAPK/ERK Pathway Metabolic Enzyme/Protease Immunology/Inflammation
  3. NF-κB p38 MAPK Adenosine Deaminase Interleukin Related
  4. Eupalestin

Eupalestin 是一种抗炎剂。Eupalestin 可降低 p-p65 NF-κB 和 p-p38 MAPK 水平。Eupalestin 可抑制 MPO、Adenosine deaminase。Eupalestin 减少包括 IL-17A、IL-6、TNF 和 IFN-γ 在内的促炎细胞因子水平。Eupalestin 在 Carrageenan (HY-125474) 诱导的小鼠胸膜炎模型中具有抗炎活性。

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Eupalestin

Eupalestin Chemical Structure

CAS No. : 73340-44-0

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Eupalestin 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Eupalestin is an anti-inflammatory agent. Eupalestin reduces the levels of p-p65 NF-κB and p-p38 MAPK. Eupalestin inhibits MPO and adenosine deaminase. Eupalestin decreases the levels of pro-inflammatory cytokines including IL-17A, IL-6, TNF and IFN-γ. Eupalestin exerts anti-inflammatory activity in a carrageenan (HY-125474)-induced mouse pleurisy model[1].

IC50 & Target[1]

IL-17A

 

IL-6

 

体内研究
(In Vivo)

Eupalestin (2.5-10 mg/kg；腹腔注射；单次；角叉菜胶给予前 0.5 h) 在角叉菜胶诱导的小鼠胸膜炎模型中发挥强效抗炎活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss (male, 18-22 g)[1]
Dosage: 2.5 mg/kg; 5 mg/kg; 10 mg/kg
Administration: i.p.; single dose; 0.5 h pre-carrageenan
Result: Significantly reduced leukocyte and neutrophil influx, and protein concentration of the pleural exudate at 5 mg/kg and 10 mg/kg (p < 0.01).
Achieved 18.3% inhibition of myeloperoxidase (MPO) concentration at 5 mg/kg (p < 0.05).
Achieved 54.6% inhibition of adenosine deaminase (ADA) concentration at 5 mg/kg (p < 0.01).
Achieved 80.8% inhibition of nitric oxide metabolites (NOx) concentration at 5 mg/kg (p < 0.05).
Significantly reduced levels of pro-inflammatory cytokines interleukin 17A (IL-17A), interleukin 6 (IL-6), tumor necrosis factor (TNF), and interferon gamma (IFN-γ) in pleural exudate at 5 mg/kg (p < 0.05).
Significantly reduced phosphorylation of p65 subunit of NF-κB (p-p65 NF-κB) and p38 mitogen-activated protein kinases (p-p38 MAPK) in lung tissue at 5 mg/kg (p < 0.01).
分子量

416.38

Formula

C21H20O9
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Eupalestin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eupalestin73340-44-0NF-κBp38 MAPKAdenosine DeaminaseInterleukin RelatedNuclear factor-κBNuclear factor-kappaBILp38 mitogen-activated protein kinasesnitric oxide metabolitesp-p65 NF-κBleukocytep-p38 MAPKIL-17Acarrageenan-induced mouse pleurisy modelmyeloperoxidaseadenosine deaminaseInhibitorinhibitorinhibit

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