2. Apoptosis Immunology/Inflammation
  3. TNF Receptor Interleukin Related
  4. Eupalinolide C

Eupalinolide C 是一种倍半萜内酯类抗炎活性物质，可在林泽兰 (Eupatorium lindleyanum) 的地上部分中发现。Eupalinolide C 可降低 LPS (HY-D1056) 刺激的小鼠巨噬细胞 RAW 264.7 中促炎细胞因子 TNF-α 和 IL-6 的水平。

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Eupalinolide C

Eupalinolide C Chemical Structure

CAS No. : 1000865-06-4

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Eupalinolide C 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Eupalinolide C is a sesquiterpene lactone and anti-inflammatory agent found in the aerial parts of Eupatorium lindleyanum.Eupalinolide C reduces levels of pro-inflammatory cytokines TNF-α and IL-6 in LPS (HY-D1056)-stimulated murine macrophage RAW 264.7 cells[1].

IC50 & Target[1]

IL-6

 

体外研究
(In Vitro)

Eupalinolide C (2.5-40 μM; 28 h) 可呈剂量依赖性抑制 RAW 264.7 细胞中 LPS 诱导的 IL-6 和 TNF-α 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Eupalinolide C 相关抗体:

ELISA Assay[1]

Cell Line: murine macrophage RAW 264.7 cells
Concentration: 2.5, 10 and 40 μM
Incubation Time: 4 h (pretreatment); 24 h (LPS stimulation)
Result: Significantly reduced LPS-induced IL-6 and TNF-α production relative to the LPS-treated control at 40 μM.
Significantly reduced LPS-induced IL-6 production relative to the LPS-treated control and TNF-α production at 10 μM.
Significantly reduced LPS-induced IL-6 and TNF-α production relative to the LPS-treated control (p < 0.01 for both) at 2.5 μM.
分子量

420.45

Formula

C22H28O8
CAS 号
中文名称

野马追内酯C
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Eupalinolide C 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eupalinolide C1000865-06-4野马追内酯CTNF ReceptorInterleukin RelatedTumor Necrosis Factor ReceptorTNFRILIL-6lipopolysaccharideanti-inflammatory agentmurine macrophage RAW 264.7 cellsTNF-αpro-inflammatory cytokinesEupatorium lindleyanumsesquiterpene lactoneInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-N8149A
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