2. Immunology/Inflammation
  3. Complement System
  4. Factor B-IN-8

Factor B-IN-8 (Compound (3R ,4R )-15) 是一种强效、选择性且具有口服活性的 B 因子 (factor B) 抑制剂，其 IC50 值为 10.2 nM。Factor B-IN-8 能有效抑制 B 因子与 C3b 的结合以及后续 C3 转化酶 (C3bBb) 的形成。Factor B-IN-8 可抑制旁路途径介导的膜攻击复合物 (MAC) 的沉积，其 IC50 值为 59.3 nM 。Factor B-IN-8 能够减少 B 因子蛋白的裂解，并降低补体 C3d 在肾小球和肾小管中的沉积。BFactor B-IN-8 可用于关节炎和阵发性睡眠性血红蛋白尿 (PNH) 的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Factor B-IN-8

Factor B-IN-8 Chemical Structure

CAS No. : 3049710-19-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Factor B-IN-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Factor B-IN-8 (Compound (3R ,4R )-15) is a potent, selective and orally active factor B inhibitor with an IC50 of 10.2 nM. Factor B-IN-8 can effectively inhibit the binding of factor B to C3b and the subsequent formation of C3 convertase (C3bBb). Factor B-IN-8 can inhibit the deposition of membrane attack complex (MAC) mediated by alternativepathway with an IC50 of 59.3 nM. Factor B-IN-8 can reduce the cleavage of factor B protein and decrease the deposition of complement C3d in the glomeruli and renal tubules. Factor B-IN-8 can be used for researches of arthritis and paroxysmal nocturnal hemoglobinuria (PNH)[1].

药代动力学
(Parmacokinetics)
Species Dose Route Indicator value
Dog[1] 3 mg/kg i.v. T1/2 3.16 h
Dog[1] 6 mg/kg i.g. Tmax 0.46 h
Rat[1] 10 mg/kg i.v. T1/2 10.58 h
Rat[1] 20 mg/kg i.g. Tmax 0.38 h
Dog[1] 3 mg/kg i.v. Cmax 14947 ng/mL
Dog[1] 6 mg/kg i.g. T1/2 5.83 h
Rat[1] 10 mg/kg i.v. Cmax 16788 ng/mL
Rat[1] 20 mg/kg i.g. T1/2 9.28 h
Dog[1] 3 mg/kg i.v. AUC0-t 8333 ng·h/mL
Dog[1] 6 mg/kg i.g. Cmax 4680 ng/mL
Rat[1] 10 mg/kg i.v. AUC0-t 11413 ng·h/mL
Rat[1] 20 mg/kg i.g. Cmax 2659 ng/mL
Dog[1] 3 mg/kg i.v. AUC0-∞ 9487 ng·h/mL
Dog[1] 6 mg/kg i.g. AUC0-t 14388 ng·h/mL
Rat[1] 10 mg/kg i.v. AUC0-∞ 15313 ng·h/mL
Rat[1] 20 mg/kg i.g. AUC0-t 8793 ng·h/mL
Dog[1] 3 mg/kg i.v. Vss 1.23 L/kg
Dog[1] 6 mg/kg i.g. AUC0-∞ 16738 ng·h/mL
Rat[1] 10 mg/kg i.v. Vss 9.18 L/kg
Rat[1] 20 mg/kg i.g. AUC0-∞ 13505 ng·h/mL
Dog[1] 6 mg/kg i.g. F 86.77 %
Rat[1] 20 mg/kg i.g. F 51.82 %
分子量

462.46

Formula

C24H25F3N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Factor B-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Factor B-IN-83049710-19-9Complement SystemInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Factor B-IN-8
目录号：
HY-181040
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z