2. Protein Tyrosine Kinase/RTK
  3. FAK
  4. FAK activator-1

FAK activator-1 (5aHCl) 是一种 FAK 激活剂和黏膜愈合诱导剂。FAK activator-1 可提高 FAK 在 Tyr-397 位点的磷酸化水平，从而促进 FAK 激活。FAK activator-1 可促进黏膜愈合。FAK activator-1 可用于非甾体抗炎药相关胃肠道黏膜损伤的研究。

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FAK activator-1

FAK activator-1 Chemical Structure

CAS No. : 2769848-56-6

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FAK activator-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FAK activator-1 is a FAK activator and mucosal healing inducer.FAK activator-1 increases FAK phosphorylation at Tyr-397, promoting FAK activation.FAK activator-1 promotes mucosal healing.FAK activator-1 can be used for the research of nsaid-associated gastrointestinal mucosal injury[1].

体外研究
(In Vitro)

FAK activator-1 (5aHCl) (10-100 nM; 1 h) 可激活悬浮状态下的 Caco-2 细胞中的 FAK[1]。
FAK activator-1 (5aHCl) (100 nM; 24 h) 可通过增强细胞迁移 (而非增殖) 促进 Caco-2 肠上皮单层的伤口愈合[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FAK activator-1 相关抗体:

Western Blot Analysis[1]

Cell Line: human Caco-2 intestinal epithelial cells
Concentration: 10 nM, 100 nM
Incubation Time: 1 h
Result: Increased the ratio of FAK-Tyr-397 phosphorylation to total FAK protein by 1.25 ± 0.08-fold at 10 nM compared to vehicle control.
Increased the ratio of FAK-Tyr-397 phosphorylation to total FAK protein by 1.25 ± 0.08-fold at 100 nM compared to vehicle control.

Cell Migration Assay[1]

Cell Line: human Caco-2 intestinal epithelial cells
Concentration: 100 nM
Incubation Time: 24 h
Result: Promoted Caco-2 monolayer wound closure with an EC50 of 3.01 ± 0.52 nM.
Significantly accelerated wound closure at 100 nM compared to vehicle control.
Retained stimulatory effect on wound closure at 100 nM when co-treated with 4 mM hydroxyurea to inhibit cell proliferation.
药代动力学
(Parmacokinetics)
Species Dose Route Cmax Tmax AUC T1/2
Rat[1] 10 mg/kg p.o. 967 ng/mL 1 h 3149 mg·h/L 3 h
分子量

473.92

Formula

C21H27ClF3N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FAK activator-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAK activator-12769848-56-6FAK activator1FAK activator 1FAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinasemucosal healingintestinal epithelial monolayerTyr-397nsaid-associated gastrointestinal mucosal injuryCaco-2 cellsFocal Adhesion KinaseInhibitorinhibitorinhibit

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目录号：
HY-181487
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