2. Metabolic Enzyme/Protease
  3. 5 alpha Reductase
  4. FCE 28260

FCE 28260 是一种口服有效的 4-氮杂甾体类 5α-还原酶 (5αR) 抑制剂。FCE 28260 对人 5αR type 1 和 5αR type 2 的 IC₅₀ 分别为 36 和 3.3 nM，对人和大鼠前列腺 5αR 的 IC₅₀ 分别为 16 和 15 nM。FCE 28260 同步阻断了前列腺和外周组织的二氢睾酮 (DHT) 生成。FCE 28260 可在大鼠模型中显著抑制催化睾酮 (T) 诱导的前列腺和精囊增生，不抑制 DHT 植入模型中的前列腺生长。FCE 28260 可用于研究良性前列腺增生 (BPH) 等 DHT 依赖性疾病。

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FCE 28260

FCE 28260 Chemical Structure

CAS No. : 155651-56-2

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FCE 28260 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FCE 28260 is an orally active 4-azacyclic 5α-reductase (5αR) inhibitor. FCE 28260 exhibits IC₅₀ values for human 5αR type 1 and 5αR type 2 of 36 and 3.3 nM, respectively, and for human and rat prostates with IC₅₀ values of 16 and 15 nM, respectively. FCE 28260 simultaneously blocks the production of dihydrotestosterone (DHT) in the prostate and peripheral tissues. FCE 28260 can significantly inhibit the induction of prostatic and seminal vesicle hyperplasia by testosterone (T) in rat models, without inhibiting the growth of the prostate in DHT implantation models. FCE 28260 can be used for the studies DHT-dependent diseases such as benign prostatic hyperplasia (BPH)[1].
分子量

488.58

Formula

C28H35F3N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FCE 28260 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FCE 28260155651-56-2FCE28260FCE-282605 alpha Reductase5α-reductase5α-reductase inhibitordihydrotestosterone (DHT)benign prostatic hyperplasia (BPH)dual type 1 and type 2 inhibitionfinasterideprostate growthrat modelInhibitorinhibitorinhibit

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