2. Cell Cycle/DNA Damage Apoptosis
  3. DNA/RNA Synthesis Apoptosis
  4. FD-895

FD-895 是一种来源于聚酮天然产物的剪接体调节剂，靶向剪接体的 SF3b 亚基。FD-895 具有调节 RNA 剪接 (内含子保留、可变剪接) 和诱导癌细胞凋亡 (apoptosis) 的核心生物活性。FD-895 可用于癌症研究，如慢性淋巴细胞白血病 (CLL)。

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FD-895

FD-895 Chemical Structure

CAS No. : 147025-57-8

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3.  试用装只面向终端客户。

规格 是否有货
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100 mg   询价  
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Other Forms of FD-895:

FD-895 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FD-895 is a spliceosome modulator derived from a polyketide natural product, targeting the SF3b subunit of the spliceosome. FD-895 possesses core biological activities for regulating RNA splicing (intron retention, alternative splicing) and inducing apoptosis of cancer cells. FD-895 can be used for the research of cancer, such as chronic lymphocytic leukemia (CLL)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
23.5 nM
Compound: 1a, FD-895
Cytotoxicity against human HCT116 cells by MTT assay
Cytotoxicity against human HCT116 cells by MTT assay
[PMID: 23919277]
分子量

566.72

Formula

C31H50O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FD-895 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FD-895147025-57-8FD895FD 895DNA/RNA SynthesisApoptosisSpliceosomepolyketideSF3bRNAapoptosiscancerCLLchronic lymphocytic leukemiaInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-114461
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