2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Ferroptosis Keap1-Nrf2 Glutathione Peroxidase Reactive Oxygen Species (ROS)
  4. Ferroptosis inducer-13

Ferroptosis inducer-13 是一种 5′- 异戊二烯基化的查尔酮衍生物，它通过改变 Nrf2/xCT/GPX4 通路活性，有效诱导人非小细胞肺癌 (NSCLC) 细胞发生铁死亡 (ferroptosis)。Ferroptosis inducer-13 在体外表现出强效的抗增殖作用，并在 NSCLC 小鼠模型中抑制肿瘤生长。Ferroptosis inducer-13 可用于 NSCLC 的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Ferroptosis inducer-13

Ferroptosis inducer-13 Chemical Structure

CAS No. : 3085517-19-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Ferroptosis inducer-13 相关抗体

Top Publications Citing Use of Products

查看 Glutathione Peroxidase 亚型特异性产品:

查看所有亚型
GPX1 GPX4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ferroptosis inducer-13 is a 5′-prenylated chalcone derivative that effectively induces ferroptosis in human non-small cell lung cancer (NSCLC) cells by altering the activity of the Nrf2/xCT/GPX4 pathway. Ferroptosis inducer-13 exhibits potent anti-proliferative effects in vitro, and inhibits tumour growth in a NSCLC mouse model. Ferroptosis inducer-13 can be used for NSCLC research[1].

IC50 & Target[1]

GPX4

 

体外研究
(In Vitro)

Ferroptosis inducer-13 (compound 4a) (72 小时) 对癌细胞表现出强效的广谱抗增殖活性，IC50 值分别为 2.11 μM (PC9)、2.17 μM (MDA-MB-231)、3.81 μM (SMMC-7721) 和 4.10 μM (SGC-7901)[1]。
Ferroptosis inducer-13 (0-40 μM；24-72 小时) 以剂量依赖及时间依赖性的方式抑制 NSCLC 细胞 (PC9 和 H1975) 增殖[1]。
Ferroptosis inducer-13 (20 μM；24 小时) 可诱导非小细胞肺癌细胞 (PC9 和 H1975) 发生铁死亡[1]。
Ferroptosis inducer-13 (0-40 μM；24 小时) 导致 GSH 耗竭，增加 Fe2+、ROS 和 LPO 水平，并通过调节 PC9 和 H1975 细胞中的 Nrf2/xCT/GPX4 信号通路诱导铁死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis inducer-13 相关抗体:

Cell Viability Assay[1]

Cell Line: PC9, H1975
Concentration: 0, 2.5, 5, 10, 20, 40 μM
Incubation Time: 24, 48, 72 h
Result: Gradually decreased cell viability of PC9 and H1975 cells in a concentration manner.
Exhibited significant anti-proliferative effects on NSCLC cells (PC9 and H1975) in a time- and concentration-dependent manner.

Cell Viability Assay[1]

Cell Line: PC9, H1975
Concentration: 20 μM
Incubation Time: 12 h
Result: Significantly enhanced cell viability by approximately 20% when combined with ferroptosis inhibitor.

Immunofluorescence[1]

Cell Line: PC9, H1975
Concentration: 20 μM
Incubation Time: 24 h
Result: Moderately reversed the GPX expression when combined with ferroptosis inhibitor.

Western Blot Analysis[1]

Cell Line: PC9, H1975
Concentration: 0, 5, 10, 20, 40 μM
Incubation Time: 24 h
Result: Significantly decreased Nrf2 levels in both cytoplasmic and nuclear fractions while reducing xCT and GPX4 expression.
体内研究
(In Vivo)

Ferroptosis inducer-13 (2 和 5 mg/kg；腹腔注射；每 3 天一次，持续 18 天) 可抑制 PC9 异种移植小鼠模型中的肿瘤生长，且具有良好的安全性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c nude mice (16-20 g) subcutaneously injected with PC9 cells[1]
Dosage: 2, 5 mg/kg
Administration: i.p.; every 3 days for 18 days
Result: Exhibited tumor growth suppression with minimal impact on body weight.
Caused no significant organ toxicity in mice.
Significantly downregulated the protein expression of xCT and GPX4 in tumor tissues compared with the control group.
分子量

337.41

Formula

C21H23NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ferroptosis inducer-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis inducer-133085517-19-4Ferroptosis inducer13Ferroptosis inducer 13FerroptosisKeap1-Nrf2Glutathione PeroxidaseReactive Oxygen Species (ROS)ferroptosisanticancer agentsNrf2/xCT/GPX4 axisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Ferroptosis inducer-13
目录号：
HY-179481
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z