2. Apoptosis
  3. Apoptosis
  4. FLQY2

FLQY2 是一种喜树碱类似物，对多种实体肿瘤具有优异的抗肿瘤功效。FLQY2 具有体内和体外抗胰腺癌活性，在纳摩尔浓度下抑制细胞增殖、集落形成、诱导细胞凋亡 (Apoptosis) 并导致细胞周期停滞。

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FLQY2

FLQY2 Chemical Structure

CAS No. : 794512-88-2

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FLQY2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FLQY2 is a camptothecin analog that exhibits outstanding antitumor efficacy against various solid tumors. FLQY2 possesses both in vitro and in vivo anti-pancreatic cancer activity, inhibiting cell proliferation, colony formation, inducing apoptosis, and causing cell cycle arrest at nanomolar concentrations[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
78.9 nM
Compound: FL77-20
Growth inhibition of human A549 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human A549 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
[PMID: 38100041]
HCT-116 IC50
40.8 nM
Compound: FL77-20
Growth inhibition of human HCT-116 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human HCT-116 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
[PMID: 38100041]
HeLa IC50
49.5 nM
Compound: FL77-20
Growth inhibition of human HeLa cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human HeLa cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
[PMID: 38100041]
HeLa IC50
6.9 nM
Compound: 15 (table 1)
Concentration required to inhibit growth of human cervical HeLa carcinoma cell line
Concentration required to inhibit growth of human cervical HeLa carcinoma cell line
[PMID: 15454230]
HepG2 IC50
86.6 nM
Compound: FL77-20
Growth inhibition of human HepG2 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human HepG2 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
[PMID: 38100041]
MCF7 IC50
47.1 nM
Compound: FL77-20
Growth inhibition of human MCF7 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human MCF7 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
[PMID: 38100041]
PC-3 IC50
13.4 nM
Compound: 15 (table 1)
Concentration required to inhibit growth of human prostate PC-3 carcinoma cell line
Concentration required to inhibit growth of human prostate PC-3 carcinoma cell line
[PMID: 15454230]
分子量

536.46

Formula

C28H19F3N2O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FLQY2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLQY2794512-88-2FLQY 2FLQY-2ApoptosisMia Paca-2pancreatic cancerapoptosisInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-162763
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