2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Fonsartan

Fonsartan (HR720) 是一种 AT1 受体拮抗剂。Fonsartan 可用于心肌梗死 (MI) 的研究。

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Fonsartan

Fonsartan Chemical Structure

CAS No. : 153235-15-5

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Fonsartan 相关抗体

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查看 Angiotensin Receptor 亚型特异性产品:

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AT1 Receptor AT2 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fonsartan (HR720) is an AT1 receptor antagonist. Fonsartan can be used for the study of myocardial infarction (MI)[1][2].

IC50 & Target

AT1 Receptor

 

体外研究
(In Vitro)

Fonsartan 选择性抑制 AT1 受体 (主要在肾上腺皮质中 (IC50 = 1.5 × 10-8 M))，而对 AT2 受体的亲和力较低 (主要在肾上腺髓质中 (IC50 = 1.4 × 10-6 M))[2]｡

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fonsartan 相关抗体:
体内研究
(In Vivo)

Fonsartan (3 mg/kg，皮下注射，每日一次，持续 6 周) 在心肌梗死 (MI) 模型大鼠中于建模后 3-24 小时开始给药时，可产生最为全面的心脏保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A myocardial infarction (MI) model was induced in male normotensive Wistar rats (weighing 250-280 g) by ligating the left anterior descending coronary artery[1].
Dosage: 3 mg/kg
Administration: S.c., once daily for 6 weeks
Result: Administration at 30 min, 3 h, 24 h, and 7 d post-administration all inhibited myocardial hypertrophy.
Administration at 3 h and 24 h post-administration significantly reduced infarct size.
Limited effect on improving left ventricular dilation (LVD, LVC).
分子量

620.87

Formula

C26H30K2N4O5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fonsartan 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fonsartan153235-15-5HR 720HR720HR-720Angiotensin ReceptorAT1 receptor antagonistRenin–angiotensin systemRASInhibitorinhibitorinhibit

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产品名称：
Fonsartan
目录号：
HY-19224
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