2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Lipoxygenase COX
  4. FPL 62064

FPL 62064 是一种有效的 5-脂氧合酶 (5-LOX) 和 COX 双重抑制剂， 对 RBL-1 胞质 5-脂氧合酶和前列腺素合成酶 (环氧化酶) 的 IC50 值分别为 3.5 μM 和 3.1 μM。FPL 62064 具有有效的抗炎活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

FPL 62064

FPL 62064 Chemical Structure

CAS No. : 103141-09-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1666
In-stock
1 mg ￥571
In-stock
5 mg ￥1500
In-stock
10 mg ￥2500
In-stock
25 mg ￥4250
In-stock
50 mg ￥6000
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

FPL 62064 相关抗体

Top Publications Citing Use of Products

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型
5-LOX 12-LOX 15-LOX

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity[1][2].

IC50 & Target

IC50: 3.5 μM (RBL-1 cytosolic 5-1ipoxygenase), and 3.1 μM (prostaglandin synthetase)[1]
体外研究
(In Vitro)

FPL 62064 inhibits both 5-1ipoxygenase (IC50 of 3.5 μM for RBL-1 cytosolic 5-1ipoxygenase) and prostaglandin synthetase (IC50 of 3.1 μM for seminal vesicle prostaglandin synthetase ) with equal facility in the isolated enzyme screens. However in the intact RBL-I cell prostaglandin synthetase (IC50 of 3.6 μM) is more readily inhibited by FPL 62064 than is 5-1ipoxygenase (IC50 of 31 μM). This difference in sensitivity is not reflected in the mouse macrophage where the IC50s for leukotriene (IC50 of 0.72 μM) and prostaglandin (IC50 of 0.43 μM) production are similar[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FPL 62064 相关抗体:
体内研究
(In Vivo)

FPL 62064 (5-20 mg/kg; intraperitoneal injection; female LACA mice) treatment inhibits peritoneal inflammation induced by immune-complex[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female LACA mice (20-30 g) injected with immune complex[1].
Dosage: 5 mg/kg, 10 mg/kg, 20 mg/kg
Administration: Intraperitoneal injection
Result: Produced a dose-related inhibition of dye extravasation, leukotriene C4 (LTC4) and prostaglandin E2 (PGE2) formation.
分子量

265.31

Formula

C16H15N3O
CAS 号
性状

固体

颜色

Light yellow to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 250 mg/mL (942.29 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7692 mL 18.8459 mL 37.6918 mL
5 mM 0.7538 mL 3.7692 mL 7.5384 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

FPL 62064 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7692 mL 18.8459 mL 37.6918 mL 94.2294 mL
5 mM 0.7538 mL 3.7692 mL 7.5384 mL 18.8459 mL
10 mM 0.3769 mL 1.8846 mL 3.7692 mL 9.4229 mL
15 mM 0.2513 mL 1.2564 mL 2.5128 mL 6.2820 mL
20 mM 0.1885 mL 0.9423 mL 1.8846 mL 4.7115 mL
25 mM 0.1508 mL 0.7538 mL 1.5077 mL 3.7692 mL
30 mM 0.1256 mL 0.6282 mL 1.2564 mL 3.1410 mL
40 mM 0.0942 mL 0.4711 mL 0.9423 mL 2.3557 mL
50 mM 0.0754 mL 0.3769 mL 0.7538 mL 1.8846 mL
60 mM 0.0628 mL 0.3141 mL 0.6282 mL 1.5705 mL
80 mM 0.0471 mL 0.2356 mL 0.4711 mL 1.1779 mL
100 mM 0.0377 mL 0.1885 mL 0.3769 mL 0.9423 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FPL 62064103141-09-9FPL62064FPL-62064LipoxygenaseCOXLOXCyclooxygenaseProstaglandinsynthetase5-lipoxygenaseanti-inflammatoryCOX-25-LOXInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
FPL 62064
目录号：
HY-105024
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

selectProvice('河北省')}">河北省
  • 黑龙江省
  • 河南省
  • 湖北省
  • 湖南省
  • 海南省

    • J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z