2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel Immunology/Inflammation
  3. Formyl Peptide Receptor (FPR) Calcium Channel Interleukin Related NO Synthase
  4. FPR2 agonist 5

FPR2 agonist 5 是一种选择性的甲酰肽受体 2 (FPR2) 激动剂。FPR2 agonist 5 在转染 FPR2 的 HL60 细胞中诱导 Ca2+ 动员，其 EC50 值为 1.2 μM，并导致 FPR2 脱敏，其 IC50 值为 0.32 μM。FPR2 agonist 5 通过减轻 LPS (HY-D1056) 诱导的小鼠原代小胶质细胞中的 LDH 释放、NO 产生以及 IL-1β、IL-6、IL-33 和 IL-10 水平，发挥神经保护作用。FPR2 agonist 5 可用于神经炎症相关疾病和炎症性疾病研究。

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FPR2 agonist 5

FPR2 agonist 5 Chemical Structure

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FPR2 agonist 5 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 NO Synthase 亚型特异性产品:

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nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FPR2 agonist 5 is a selective Formyl Peptide Receptor 2 (FPR2) agonist. FPR2 agonist 5 induces Ca2+ mobilization in FPR2-HL60 transfected cells with an EC50 of 1.2 μM and causes FPR2 desensitization with an IC50 of 0.32 μM. FPR2 agonist 5 exerts neuroprotective effects by mitigating LDH release, NO production, IL-1β, IL-6, IL-33, and IL-10 levels in LPS (HY-D1056)-induced mouse primary microglial cells. FPR2 agonist 5 can be used for the study of neuroinflammatory-related diseases[1].

体外研究
(In Vitro)

FPR2 agonist 5 (Compound (S)-9a) (1 μM, 1 h pretreatment) 减轻 LPS 诱导的小鼠原代小胶质细胞中的 LDH 释放和 NO 产生[1]。
FPR2 agonist 5 (1 μM, 1 h pretreatment) 降低 LPS 诱导的小鼠原代小胶质细胞中 IL-1β、IL-6、IL-33 和 IL-10 水平的增加[1]。
FPR2 agonist 5 诱导 Ca2+ 动员，其 EC50 值为 1.2 μM，并导致 FPR2 脱敏，其 IC50 值为 0.32 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FPR2 agonist 5 相关抗体:

ELISA Assay[1]

Cell Line: Mouse primary microglial cells
Concentration: 1 μM
Incubation Time: 1 h pretreatment
Result: Decreased LPS-induced increases in IL-1β, IL-6, IL-33, and IL-10 levels in mouse primary microglial cells.
分子量

453.47

Formula

C26H20FN5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FPR2 agonist 5 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FPR2 agonist 5Formyl Peptide Receptor (FPR)Calcium ChannelInterleukin RelatedNO SynthaseCa2+ channelsCa channelsILNitric oxide synthasesNOSneuroinflammatory-related diseasesFPR2LDH releaseNO productionInhibitorinhibitorinhibit

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产品名称：
FPR2 agonist 5
目录号：
HY-178144
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