2. Anti-infection
  3. Bacterial
  4. FuK

FuK 是经氟代非天然氨基酸修饰的 WK2 类似物抗菌肽。FuK 在小鼠中 LD50 为 72.34 mg/kg，无溶血活性，对胰蛋白酶、胰凝乳蛋白酶及含盐环境稳定性高。FuK 通过增强细菌外膜通透性、诱导细胞质膜去极化并破坏膜电位平衡发挥杀菌作用，对金黄色葡萄球菌、大肠杆菌、肺炎克雷伯菌及 MRSA 等革兰氏阳性菌和革兰氏阴性菌有效。FuK 可与 Polymyxin B (HY-149179)，Vancomycin (HY-B0671) 和 Ciprofloxacin (HY-B0356) 协同抗菌，还能抑制环丙沙星诱导的细菌耐药性。FuK 具有体内安全性，有效减少小鼠 MRSA 模型的细菌载量与炎症细胞浸润，促进皮肤伤口胶原纤维形成。

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Custom Peptide Synthesis

FuK

FuK Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

FuK 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FuK is a WK2-analog antimicrobial peptide modified with fluorinated unnatural amino acids. FuK has an LD50 of 72.34 mg/kg in mice, shows no hemolytic activity, with high stability against trypsin, chymotrypsin, and saline environments. FuK exerts bactericidal effects by enhancing the permeability of bacterial outer membranes, inducing depolarization of cytoplasmic membranes, and disrupting membrane potential balance against bacterias such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and MRSA. FuK exhibits synergistic antimicrobial activity with polymyxin B (HY-149179), vancomycin (HY-B0671), and ciprofloxacin (HY-B0356), and also inhibits Ciprofloxacin-induced bacterial drug resistance. FuK has in vivo safety, effectively reduces bacterial load and inflammatory cell infiltration in a mouse MRSA model, and promotes collagen fiber formation in skin wounds[1].
体内研究
(In Vivo)

FuK (5-10 mg/kg; i.p.; 感染后 4 和 12 小时给药) 剂量依赖性抑制 BALB/c 小鼠中 K. pneumoniae 诱导的肺部感染，可降低细菌载量并减少炎性细胞浸润[1]。
FuK (5-10 mg/kg；局部给药；感染后 4、12 和 24 小时给药) 可有效改善 BALB/c 小鼠中由 MRSA 诱导的皮肤伤口感染，促进伤口愈合并降低细菌载量与炎性细胞浸润[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (male, 6−8 weeks old, 18−20 g) challenged with nebulized K. pneumoniae suspension[1]
Dosage: 5 mg/kg; 10 mg/kg
Administration: i.p.; at 4 and 12 h post-infection
Result: Reduced K. pneumoniae lung burden to 5.32 × 105 CFU/mg (5 mg/kg dose) and 3.71 × 105 CFU/mg (10 mg/kg dose).
Caused slight alveolar dilation and reduced inflammatory cell infiltration, with enhanced therapeutic effects at higher doses.
分子量

1560.62

Formula

C72H97F12N15O10
Sequence

Gly-{Fup}-{Fup}-{d-Lys}-{d-Lys}-{Fup}-{Fup}-{d-Lys}-{d-Lys}-Ile-NH2
Sequence Shortening

G-{Fup}-{Fup}-{d-Lys}-{d-Lys}-{Fup}-{Fup}-{d-Lys}-{d-Lys}-I-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FuK 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FuKBacterialKlebsiella pneumoniaemethicillin-resistant S. aureusbiofilmBALB/c miceEscherichia colibacterial cytoplasmic membraneStaphylococcus aureusGram-negative bacteriabacterial outer membraneGram-positive bacteriaInhibitorinhibitorinhibit

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