2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. G194-0712

G194-0712 是一种选择性组蛋白去乙酰化酶 5 (HDAC5) 激活剂，其 EC50 为 7.96 μM，Kd 为 2.53 μM。G194-0712 可恢复 ACTN4-K417 的去乙酰化及核转位，并上调 CSTA 的表达水平。G194-0712 可加速慢性伤口模型中的伤口闭合，缩小伤口面积与上皮间隙。G194-0712 可用于慢性皮肤伤口的相关研究，如糖尿病伤口、缺血性伤口、放射性损伤伤口。

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G194-0712

G194-0712 Chemical Structure

CAS No. : 1029737-28-7

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G194-0712 相关抗体

Top Publications Citing Use of Products

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

G194-0712 is a selective histone deacetylase 5 (HDAC5) activator with an EC50 of 7.96 μM and a Kd of 2.53 μM. G194-0712 restores ACTN4-K417 deacetylation and nuclear import, and increases CSTA expression. G194-0712 accelerates wound closure in chronic wound models, reducing wound area and epithelial gap. G194-0712 can be used for the research of chronic skin wounds, such as diabetic wounds, ischemic wounds, radiation injury wounds[1].

IC50 & Target[1]

HDAC5

7.96 μM (EC50)

HDAC5

2.53 μM (Kd)

体外研究
(In Vitro)

G194-0712 对 HDAC4、HDAC7 和 HDAC9 表现出的 EC50 值分别为 107.2、100.4 和 111.5 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

G194-0712 相关抗体:
体内研究
(In Vivo)

G194-0712 (25 μM；局部给药) 可通过恢复 ACTN4-K417 的去乙酰化、核转运及 CSTA 的表达，缩小 C57BLKS/J-db/db 小鼠的创面面积并减少上皮间隙，进而加速糖尿病小鼠的创面愈合和 C57BL/6J 小鼠缺血性、放射性损伤伤口的愈合[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BLKS/J-db/db (male, 8 weeks old, chronic wound model); C57BL/6J mice (male, 8 weeks old)[1]
Dosage: 25 μM
Administration: Topical application
Result: Reinstated ACTN4-K417 deacetylation and nuclear import.
Increased CSTA expression and reduced wound area at PODs 5, 9, 14, and 18.
Decreased epithelial gap.
分子量

353.85

Formula

C20H20ClN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

G194-0712 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

G194-07121029737-28-7HDACHistone deacetylasesHDAC5Histone deacetylase 5CSTAACTN4-K417diabetic woundsradiation injury woundsC57BLKS/J-db/dbchronic skin woundsischemic woundsInhibitorinhibitorinhibit

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产品名称：
G194-0712
目录号：
HY-181126
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