2. Anti-infection
  3. Orthopoxvirus
  4. G243-1720

G243-1720 是一种强效、口服有效、广谱的抗正痘病毒剂，通过靶向 OPG57 (F13) 蛋白并诱导其二聚化来发挥作用。G243-1720 有效抑制多种正痘病毒的复制，但对非正痘病毒无抑制作用。G243-1720 阻止了细胞外膜病毒粒子的形成和细胞间的传播。G243-1720 显著降低了小鼠肺部猴痘病毒 (MPXV) 的病毒载量。

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G243-1720

G243-1720 Chemical Structure

CAS No. : 932311-85-8

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G243-1720 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

G243-1720 is a potent, orally active, broad-spectrum anti-orthopoxvirus agent that functions by targeting the OPG57 (F13) protein and inducing its dimerization. G243-1720 effectively inhibits the replication of various poxviruses, but has no inhibitory effect on non-poxviruses. G243-1720 prevents the formation of extracellular membrane virus particles and the spread between cells. G243-1720 significantly reduces the viral load of monkeypox virus (MPXV) in the lungs of mice[1]

分子量

437.98

Formula

C21H28ClN3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

G243-1720 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G243-1720932311-85-8OrthopoxvirusMpox virusReplication-defective virusAntiviral screeningOPG57 (F13L)TecovirimatDimerizationBroad-spectrum activityInhibitorinhibitorinhibit

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目录号：
HY-180785
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