2. Cell Cycle/DNA Damage
  3. IRE1
  4. G6374

G6374 是一种 IRE1 PROTAC 降解剂，其 DC50 值为 0.04 μM。G6374 可有效诱导 IRE1 的泛素化和降解。G6374 可选择性抑制 IRE1 依赖性癌细胞的增殖。
(粉色: Ligands for Target Protein for PROTAC 和 IRE1 配体 (HY-180780)；蓝色: Ligands for E3 Ligase 和 VHL 配体 (HY-125845)；黑色: 连接子 (HY-W041652))。

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G6374

G6374 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

G6374 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

G6374 is an IRE1 PROTAC degrader with a DC50 of 0.04 μM. G6374 induces efficient ubiquitination and degradation of IRE1. G6374 selectively inhibits IRE1-dependent cancer-cell proliferation[1]. (Pink: Ligands for Target Protein for PROTAC and IRE1 ligand (HY-180780); Blue: Ligands for E3 Ligase and VHL ligand (HY-125845); Black: linker (HY-W041652)).

IC50 & Target

DC50: 0.04 μM (IRE1)[1]
分子量

883.16

Formula

C47H66N10O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

G6374 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G6374G 6374G-6374IRE1Inositol requiring enzyme 1PROTACcancerInhibitorinhibitorinhibit

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Inquiry Information

产品名称：
G6374
目录号：
HY-180787
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