2. Cell Cycle/DNA Damage
  3. Cyclin G-associated Kinase (GAK)
  4. GAK-IN-3

GAK-IN-3 是一种细胞周期蛋白 G 相关激酶 (GAK) 抑制剂，其 IC50 为 207 nM，Ki 为 66 nM。GAK-IN-3 通过结合 GAK 的 ATP 结合位点，在纳摩尔水平抑制激酶活性。GAK-IN-3 降低尤因肉瘤细胞的存活率。GAK-IN-3 可用于尤因肉瘤的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

GAK-IN-3

GAK-IN-3 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

GAK-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GAK-IN-3 is a cyclin G-associated kinase (GAK) inhibitor with an IC50 of 207 nM and a Ki of 66 nM. GAK-IN-3 inhibits kinase activity in the nanomolar range by binding to GAK’s ATP-binding site. GAK-IN-3 acts as a cytotoxic agent that reduces viability of Ewing sarcoma cells. GAK-IN-3 can be used for the research of ewing sarcoma[1].

IC50 & Target[1]

GAK

207 nM (IC50)

GAK

66 nM (Ki)

体外研究
(In Vitro)

GAK-IN-3 (compound 3c) (10 μM；48 h) 可将 RD-ES 细胞活力降至 25.7%，将 Daoy 细胞活力降至 44.6%[1]。
GAK-IN-3 (0.225-7.2 μM；作用 48 h) 可抑制 RD-ES 细胞活力，其 IC50 为 1.1 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GAK-IN-3 相关抗体:

Cell Viability Assay[1]

Cell Line: RD‐ES (Ewing Sarcoma), Daoy (medulloblastoma)
Concentration: 10 μM
Incubation Time: 48 h
Result: Reduced RD‐ES cell viability to 25.7% and Daoy cell viability to 44.6% at 10 μM after 48 h incubation.

Cell Viability Assay[1]

Cell Line: RD‐ES
Concentration: 7.2, 3.6, 1.8,
0.9, 0.45, and 0.225 μM
Incubation Time: 48 h
Result: Inhibited RD‐ES cell viability with an IC50 of 1.1 μM after 48 h incubation.
分子量

349.45

Formula

C19H19N5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GAK-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GAK-IN-3Cyclin G-associated Kinase (GAK)Auxilin 2RD‐ES cellewing sarcomabackbone amide groupsGAKCyclin G-associated kinaseDaoy cellhydrophobic regionATP-binding sitepurified recombinant kinasesEwing sarcoma cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
GAK-IN-3
目录号：
HY-181169
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z