2. Immunology/Inflammation
  3. Galectin
  4. Galectin-3-IN-7

Galectin-3-IN-7 是一种选择性的 Galectin-3 抑制剂，其 Kd 值为 5.7 nM，对 Gal-1 的选择性高 390 倍。Galectin-3-IN-7 可下调 TGFβ 刺激的 LX2 肝星状细胞中促纤维化信号通路，如 ACTA2、COL1A2 和 FN1。Galectin-3-IN-7 可用于纤维化研究。

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Galectin-3-IN-7

Galectin-3-IN-7 Chemical Structure

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Galectin-3-IN-7 相关抗体

Top Publications Citing Use of Products

查看 Galectin 亚型特异性产品:

查看所有亚型
Galectin-1 Galectin-3 Galectin-4 Galectin-8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Galectin-3-IN-7 is a selective Galectin-3 inhibitor with a Kd of 5.7 nM and shows 390-fold selectivity over Gal-1. Galectin-3-IN-7 can downregulate profibrotic signaling such as ACTA2, COL1A2, and FN1 in TGFβ-stimulated LX2 hepatic stellate cells. Galectin-3-IN-7 can be used for the research of fibrosis[1].
IC50 & Target[1]

Galectin-3

5.7 nM (Kd)

体外研究
(In Vitro)

Galectin-3-IN-7 (Compound 11) 在人、小鼠和大鼠血浆中的血浆蛋白结合率适中，分别为 45%、43% 和 90%[1]。
Galectin-3-IN-7 (3.7-300 μM, 24 h) 对 HEK293、HepG2、THP-1、Jurkat E6.1 和 LX2 细胞的 CC50 值均大于 300 μM[1]。
Galectin-3-IN-7 (3.7-300 μM, 24 h) 不会显著抑制 LPS (HY-D1056) 诱导的 THP-1 巨噬细胞样细胞中 TNFα 的分泌[1]。
Galectin-3-IN-7 (3.7-300 μM, 24 h) 以剂量依赖性方式下调 TGFβ1 刺激的 LX2 细胞中 ACTA2、COL1A2 和 FN1 的 mRNA 表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Galectin-3-IN-7 相关抗体:

Real Time qPCR[1]

Cell Line: LX2 cells
Concentration: 3.7, 11.1, 33.3, 100 and 300 μM
Incubation Time: 48 h
Result: Reduced the mRNA expression of ACTA2, COL1A2, and FN1.
分子量

703.69

Formula

C31H34FN5O11S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Galectin-3-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Galectin-3-IN-7GalectinHEK293HepG2THP-1Jurkat E6.1LX2TGFβ1LPSTNFαInhibitorinhibitorinhibit

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产品名称：
Galectin-3-IN-7
目录号：
HY-179410
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