2. Gene
  3. CXCR6 - C-X-C motif chemokine receptor 6 Gene

CXCR6 - C-X-C motif chemokine receptor 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CXC 基序趋化因子受体 6

种属: Homo sapiens

同用名: BONZO; CD186; CDw186; STRL33; TYMSTR

基因 ID: 10663 | 基因类型: protein coding

关于 CXCR6

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,940,915-45,948,351 (from NCBI)

This gene has 4 transcripts (splice variants), 97 orthologues and 23 paralogues. Broad expression in lymph node (RPKM 5.9), spleen (RPKM 4.9) and 19 other tissues.

功能概要

该基因编码的蛋白质是一种 G 蛋白偶联受体，具有七个跨膜结构域，属于 CXC 趋化因子受体家族。该家族还包括 CXCR1、CXCR2、CXCR3、CXCR4、CXCR5 和 CXCR7。该基因映射到趋化因子受体基因簇，在多个 T 淋巴细胞亚群和骨髓基质细胞中表达。编码的蛋白质及其独特的配体趋化因子配体 16 (CCL16) 是调节 T 淋巴细胞向各种外周组织 (肝脏、脾脏红髓、肠、肺和皮肤) 迁移并促进细胞-细胞迁移的信号通路的一部分与树突状细胞和成纤维细胞网状细胞相互作用。 CXCR6/CCL16 还控制驻留记忆 T 淋巴细胞定位到肺的不同隔室，并维持气道驻留记忆 T 淋巴细胞，这是抵御呼吸道病原体的重要第一道防线。编码的蛋白质与 CD4 一起用作 HIV-1 和 SIV 进入靶细胞的进入辅助受体。[RefSeq 提供，2020 年 8 月]

The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC Chemokine Receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the Chemokine Receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020]

CXCR6 基因产物(4)

mRNA Protein Name
NM_001386435.1 NP_001373364.1 C-X-C chemokine receptor type 6
NM_001386437.1 NP_001373366.1 C-X-C chemokine receptor type 6
NM_001386436.1 NP_001373365.1 C-X-C chemokine receptor type 6
NM_006564.2 NP_006555.1 C-X-C chemokine receptor type 6

CXCR6 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (48 - 288)

  • 0
  • 100
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  • 300
  • 342 a.a.
蛋白主名 其他名称

C-X-C chemokine receptor type 6

G protein-coupled receptor

G-protein coupled receptor STRL33

G-protein coupled receptor bonzo

chemokine (C-X-C motif) receptor 6

CXCR6 抗体

目录号 产品名 应用 反应物种
HY-P83796 CD186 Antibody (YA3493) WB, FC, ELISA Human

关联疾病

疾病名称 别名
Type 1 Diabetes Mellitus 22

Diabetes Mellitus, Insulin-Dependent, 22

IDDM22

T1D22

Insulin-Dependent Diabetes Mellitus 22

Diabetes Mellitus, Insulin-Dependent, Type 22
Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency Disease

Primary Immunodeficiency

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm
Cataract 44

CTRCT44

Total Early-Onset Cataract

Cataract 44 And Hypotrichosis

Cataract And Hypotrichosis

Cataract, Type 44
Sarcoidosis 1

Sarcoidosis

Boeck Sarcoid

Besnier-Boeck-Schaumann Disease

SS1

Sarcoidosis, Susceptibility To, 1

Lymphogranulomatosis

Hodgkin Disease

Boeck'S Disease

Boeck'S Sarcoid

Schaumann'S Disease Or Syndrome

Hutchinson-Boeck Disease Or Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-122197 ML339 Antagonist 99.88% 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CXCR6 MGD MGI:1934582
Rattus norvegicus CXCR6 RGD RGD:1642118
Bos taurus CXCR6 VGNC VGNC:27858
Macaca mulatta CXCR6 VGNC VGNC:71423
Canis familiaris CXCR6 VGNC VGNC:39753
Felis catus CXCR6 VGNC VGNC:61300
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