2. Gene
  3. Prkaa2 - protein kinase, AMP-activated, alpha 2 catalytic subunit Gene

Prkaa2 - protein kinase, AMP-activated, alpha 2 catalytic subunit Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: A830082D05; AMPKalpha2; 2310008I11Rik

基因 ID: 108079 | 基因类型: protein coding

关于 Prkaa2

功能概要

Enables AMP-activated protein kinase activity; chromatin binding activity; and histone serine kinase activity. Involved in several processes, including regulation of autophagy; regulation of organelle organization; and regulation of protein modification process. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; cellular response to xenobiotic stimulus; and response to muscle activity. Located in several cellular components, including cytoplasmic stress granule; dendrite; and neuronal cell body. Is expressed in several structures, including brain; genitourinary system; gut; lung; and spinal cord. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Prkaa2 基因产物(2)

mRNA Protein Name
NM_001356568.1 NP_001343497.1 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 2
NM_178143.2 NP_835279.2 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables AMP-activated protein kinase activity IDA
IDA: 通过直接分析推断
18439900 MGI
enables AMP-activated protein kinase activity IGI
IGI: 通过遗传相互作用推断
25788287 MGI
enables AMP-activated protein kinase activity IMP
IMP: 通过突变表型推断
16308421 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
20647423 MGI
enables histone H2BS36 kinase activity IDA
IDA: 通过直接分析推断
20647423 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19833968 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
32912901 MGI
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
16308421 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to calcium ion IGI
IGI: 通过遗传相互作用推断
25788287 MGI
involved in cellular response to glucose starvation IDA
IDA: 通过直接分析推断
21258367 MGI
involved in cellular response to glucose stimulus IGI
IGI: 通过遗传相互作用推断
25788287 MGI
involved in cellular response to nutrient levels IDA
IDA: 通过直接分析推断
21258367 MGI
involved in cellular response to oxidative stress IGI
IGI: 通过遗传相互作用推断
27430620 MGI
acts upstream of or within cellular response to prostaglandin E stimulus IGI
IGI: 通过遗传相互作用推断
23479225 MGI
acts upstream of or within cellular response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
23918774 MGI
involved in glucose homeostasis IMP
IMP: 通过突变表型推断
16308421 MGI
involved in lipid biosynthetic process IDA
IDA: 通过直接分析推断
21459323 MGI
involved in negative regulation of TOR signaling IMP
IMP: 通过突变表型推断
18439900 MGI
involved in negative regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
32912901 MGI
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
18439900 MGI
involved in negative regulation of gene expression IGI
IGI: 通过遗传相互作用推断
27430620 MGI
involved in negative regulation of tubulin deacetylation IGI
IGI: 通过遗传相互作用推断
27430620 MGI
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
21258367 MGI
involved in positive regulation of peptidyl-lysine acetylation IGI
IGI: 通过遗传相互作用推断
27430620 MGI
involved in positive regulation of protein localization IGI
IGI: 通过遗传相互作用推断
27430620 MGI
involved in protein localization to lipid droplet IDA
IDA: 通过直接分析推断
34077757 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
23332761 MGI
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
19833968 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
23918774 MGI
involved in regulation of macroautophagy IDA
IDA: 通过直接分析推断
23332761 MGI
involved in regulation of microtubule cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
27430620 MGI
involved in regulation of stress granule assembly IGI
IGI: 通过遗传相互作用推断
27430620 MGI
acts upstream of or within response to muscle activity IMP
IMP: 通过突变表型推断
23918774 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IGI
IGI: 通过遗传相互作用推断
25788287 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
30201684 MGI
located in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
27430620 MGI
located in dendrite IGI
IGI: 通过遗传相互作用推断
25788287 MGI
located in neuronal cell body IGI
IGI: 通过遗传相互作用推断
25788287 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10098881 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

5'-AMP-activated protein kinase catalytic subunit alpha-2

ACACA kinase

AMPK subunit alpha-2

HMGCR kinase

acetyl-CoA carboxylase kinase

hydroxymethylglutaryl-CoA reductase kinase

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS21177 Prkaa2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS11101 PRKAA2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27694 Prkaa2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkaa2 NCBI NCBI:5563
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