2. Gene
  3. Mthfd1 - methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase Gene

Mthfd1 - methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Dcs; Mthfd; E430024A07Rik

基因 ID: 108156 | 基因类型: protein coding

关于 Mthfd1

功能概要

This gene encodes a trifunctional cytoplasmic enzyme. The encoded protein functions as a methylenetetrahydrofolate dehydrogenase, a methenyltetrahydrofolate cyclohydrolase, and a formyltetrahydrofolate synthase. The encoded enzyme functions in de novo synthesis of purines and thymidylate and in regeneration of methionine from homocysteine. [provided by RefSeq, Oct 2009]

Mthfd1 基因产物(1)

mRNA Protein Name
NM_138745.2 NP_620084.2 C-1-tetrahydrofolate synthase, cytoplasmic
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables formate-tetrahydrofolate ligase activity IMP
IMP: 通过突变表型推断
15611115 MGI
enables methylenetetrahydrofolate dehydrogenase (NAD+) activity IDA
IDA: 通过直接分析推断
23704330 MGI
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IMP
IMP: 通过突变表型推断
15611115 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 10-formyltetrahydrofolate biosynthetic process IMP
IMP: 通过突变表型推断
23704330 MGI
involved in heart development IMP
IMP: 通过突变表型推断
23704330 MGI
involved in methionine metabolic process IMP
IMP: 通过突变表型推断
23190757 MGI
involved in neural tube closure IMP
IMP: 通过突变表型推断
23704330 MGI
involved in neutrophil homeostasis IMP
IMP: 通过突变表型推断
23704330 MGI
involved in purine nucleotide biosynthetic process IMP
IMP: 通过突变表型推断
23704330 MGI
acts upstream of purine ribonucleotide biosynthetic process IMP
IMP: 通过突变表型推断
15611115 MGI
involved in serine family amino acid metabolic process IMP
IMP: 通过突变表型推断
23190757 MGI
involved in somite development IMP
IMP: 通过突变表型推断
23704330 MGI
involved in tetrahydrofolate interconversion IMP
IMP: 通过突变表型推断
23704330 MGI
involved in transsulfuration IMP
IMP: 通过突变表型推断
23190757 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

C-1-tetrahydrofolate synthase, cytoplasmic

C1-THF synthase

C1-tetrahydrofolate synthase

相关产品

Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-130251 DS18561882 99.87% 否
HY-101943 LY 345899 98.0% 否
HY-155950 TH9619 99.33% 否
HY-131943 DS44960156 ≥99.0% 否
HY-155219 TH9028 Inhibitor / 否
HY-172910 MTHFD2-IN-6 Inhibitor / 否
HY-RS08774 MTHFD1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS08775 MTHFD1L Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17098 Mthfd1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20214 Mthfd1l Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23542 Mthfd1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26720 Mthfd1l Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mthfd1 NCBI NCBI:4522
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