2. Gene
  3. E2f8 - E2F transcription factor 8 Gene

E2f8 - E2F transcription factor 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 4432406C08Rik

基因 ID: 108961 | 基因类型: protein coding

关于 E2f8

功能概要

Enables DNA binding activity; DNA-binding transcription repressor activity; and identical protein binding activity. Involved in several processes, including hepatocyte differentiation; regulation of cell cycle process; and trophoblast giant cell differentiation. Acts upstream of or within cell population proliferation. Located in nucleus. Is expressed in central nervous system and retina. Orthologous to human E2F8 (E2F transcription factor 8). [provided by Alliance of Genome Resources, Apr 2022]

E2f8 基因产物(2)

mRNA Protein Name
NM_001013368.5 NP_001013386.2 transcription factor E2F8
NM_001360812.1 NP_001347741.1 transcription factor E2F8
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15722552 MGI
enables DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
22516201 MGI
enables DNA-binding transcription repressor activity IMP
IMP: 通过突变表型推断
22516201 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15722552 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell cycle comprising mitosis without cytokinesis IMP
IMP: 通过突变表型推断
23064266 MGI
involved in chorionic trophoblast cell differentiation IMP
IMP: 通过突变表型推断
22516201 MGI
acts upstream of or within fibroblast proliferation IDA
IDA: 通过直接分析推断
15722552 MGI
involved in hepatocyte differentiation IMP
IMP: 通过突变表型推断
23064264 MGI
involved in negative regulation of cytokinesis IMP
IMP: 通过突变表型推断
23064264 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22516201 MGI
involved in placenta development IMP
IMP: 通过突变表型推断
22516201 MGI
involved in positive regulation of DNA endoreduplication IMP
IMP: 通过突变表型推断
23064264 MGI
involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
22903062 MGI
involved in trophoblast giant cell differentiation IMP
IMP: 通过突变表型推断
23064266 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
15722552 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcription factor E2F8

E2f family member 8

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04117 E2F8 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22149 E2f8 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens E2f8 NCBI NCBI:79733
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