2. Gene
  3. BRD8 - bromodomain containing 8 Gene

BRD8 - bromodomain containing 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含溴结构域 8

种属: Homo sapiens

同用名: SMAP; p120; SMAP2

基因 ID: 10902 | 基因类型: protein coding

关于 BRD8

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,139,770-138,178,630 (from NCBI)

This gene has 26 transcripts (splice variants) and 291 orthologues. Broad expression in testis (RPKM 45.3), brain (RPKM 10.9) and 23 other tissues.

功能概要

由该基因编码的蛋白质以配体依赖性方式与甲状腺激素受体相互作用，并增强甲状腺反应元件的甲状腺激素依赖性激活。这种蛋白质含有溴结构域，被认为是一种核受体共激活剂。已经确定了编码不同亚型的多个选择性剪接的转录物变体。[RefSeq 提供，2014 年 7 月]

The protein encoded by this gene interacts with Thyroid Hormone Receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]

BRD8 基因产物(6)

mRNA Protein Name
NM_001164326.2 NP_001157798.1 bromodomain-containing protein 8 isoform 4
NM_001300961.3 NP_001287890.1 bromodomain-containing protein 8 isoform 5
NM_001300962.3 NP_001287891.1 bromodomain-containing protein 8 isoform 6
NM_001300966.3 NP_001287895.1 bromodomain-containing protein 8 isoform 7
NM_006696.5 NP_006687.3 bromodomain-containing protein 8 isoform 1
NM_139199.2 NP_631938.2 bromodomain-containing protein 8 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear receptor coactivator activity IDA
IDA: 通过直接分析推断
9368056 GOA
enables nuclear thyroid hormone receptor binding IPI
IPI: 通过物理相互作用推断
9368056 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to thyroid hormone stimulus IDA
IDA: 通过直接分析推断
9368056 GOA
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
27153538 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9368056 GOA
involved in regulation of cell cycle IMP
IMP: 通过突变表型推断
27153538 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NuA4 histone acetyltransferase complex IDA
IDA: 通过直接分析推断
14966270 GOA
part of Swr1 complex IDA
IDA: 通过直接分析推断
24463511 GOA
part of nucleosome IDA
IDA: 通过直接分析推断
27153538 GOA
located in nucleus IDA
IDA: 通过直接分析推断
25593309 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BRD8 蛋白结构

Bromodomain

Bromodomain: Bromodomain (725 - 798)

Bromodomain

Bromodomain: Bromodomain (1114 - 1194)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1235 a.a.
蛋白主名 其他名称

bromodomain-containing protein 8

skeletal muscle abundant protein 2

关联疾病

疾病名称 别名
Ossifying Fibromyxoid Tumor

Ossifying Fibromyxoid Tumour

Ossifying Fibromyxoma
Endometrial Stromal Tumor

Endometrial Stromal Neoplasm

Endometrial Stromal Tumors
Ovarian Sex-Cord Stromal Tumor

Ovarian Sex Cord Tumor With Annular Tubules

Ovarian Sex Cord-Stromal Tumor

Stromal Tumor Of Ovary
Endometrial Stromal Sarcoma

Ess

Endometrial Stromal Sarcoma, High Grade

Undifferentiated Endometrial Sarcoma

Stromal Sarcoma Of The Corpus Uteri

Sarcoma Endometrial Stromal

Sarcoma, Endometrial Stromal

Undifferentiated Stromal Sarcoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148116 DN02 Inhibitor 95.08% 否
HY-RS01609 BRD8 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17186 Brd8 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23637 Brd8 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BRD8 VGNC VGNC:70350
Mus musculus BRD8 MGD MGI:1925906
Felis catus BRD8 VGNC VGNC:60170
Rattus norvegicus BRD8 RGD RGD:1307003
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