2. Gene
  3. Chrna7 - cholinergic receptor, nicotinic, alpha polypeptide 7 Gene

Chrna7 - cholinergic receptor, nicotinic, alpha polypeptide 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Acra7; nAchR; alpha7

基因 ID: 11441 | 基因类型: protein coding

关于 Chrna7

功能概要

Enables acetylcholine-gated cation-selective channel activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of cell communication; and regulation of protein metabolic process. Acts upstream of or within several processes, including behavioral response to ethanol; learning or memory; and negative regulation of cytokine production. Located in apical plasma membrane; axolemma; and external side of plasma membrane. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Is active in cholinergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; retina; and thymus. Used to study schizophrenia. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion). [provided by Alliance of Genome Resources, Apr 2022]

Chrna7 基因产物(1)

mRNA Protein Name
NM_007390.3 NP_031416.3 neuronal acetylcholine receptor subunit alpha-7 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
IDA: 通过直接分析推断
9495872 MGI
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
IMP: 通过突变表型推断
9037516 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11906696 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell activation IMP
IMP: 通过突变表型推断
15963492 MGI
acts upstream of or within T cell activation IMP
IMP: 通过突变表型推断
16253349 MGI
acts upstream of or within associative learning IGI
IGI: 通过遗传相互作用推断
15541879 MGI
acts upstream of or within associative learning IMP
IMP: 通过突变表型推断
15922075 MGI
acts upstream of or within behavioral response to ethanol IMP
IMP: 通过突变表型推断
15489024 MGI
acts upstream of or within behavioral response to nicotine IGI
IGI: 通过遗传相互作用推断
17470777 MGI
involved in dendrite arborization IMP
IMP: 通过突变表型推断
23270857 MGI
involved in dendritic spine organization IMP
IMP: 通过突变表型推断
23270857 MGI
acts upstream of or within endocytosis IMP
IMP: 通过突变表型推断
16025111 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
9364063 MGI
acts upstream of or within flagellated sperm motility IMP
IMP: 通过突变表型推断
15944242 MGI
acts upstream of or within generation of ovulation cycle rhythm IMP
IMP: 通过突变表型推断
15364017 MGI
acts upstream of interleukin-1 beta production IMP
IMP: 通过突变表型推断
12508119 MGI
acts upstream of interleukin-6 production IMP
IMP: 通过突变表型推断
12508119 MGI
involved in learning or memory IGI
IGI: 通过遗传相互作用推断
19118188 MGI
acts upstream of or within memory IMP
IMP: 通过突变表型推断
16923147 MGI
involved in modulation of chemical synaptic transmission IGI
IGI: 通过遗传相互作用推断
20943921 MGI
involved in modulation of excitatory postsynaptic potential IDA
IDA: 通过直接分析推断
20974225 MGI
involved in modulation of excitatory postsynaptic potential IGI
IGI: 通过遗传相互作用推断
20974225 MGI
acts upstream of or within monoatomic ion transport IMP
IMP: 通过突变表型推断
9364063 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
16785311 MGI
acts upstream of or within negative regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
12508119 MGI
acts upstream of or within negative regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
12508119 MGI
involved in negative regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
19230830 MGI
acts upstream of or within negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
12508119 MGI
acts upstream of or within ovulation cycle IMP
IMP: 通过突变表型推断
1400473 MGI
involved in positive regulation of CoA-transferase activity IGI
IGI: 通过遗传相互作用推断
20164328 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
17898229 MGI
involved in positive regulation of ERK1 and ERK2 cascade IGI
IGI: 通过遗传相互作用推断
20164328 MGI
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
11404397 MGI
involved in positive regulation of amyloid-beta formation IGI
IGI: 通过遗传相互作用推断
20164328 MGI
involved in positive regulation of excitatory postsynaptic potential IGI
IGI: 通过遗传相互作用推断
19118188 MGI
acts upstream of or within positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure IMP
IMP: 通过突变表型推断
10942027 MGI
involved in positive regulation of long-term synaptic potentiation IDA
IDA: 通过直接分析推断
20974225 MGI
involved in positive regulation of long-term synaptic potentiation IGI
IGI: 通过遗传相互作用推断
19118188 MGI
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
19230830 MGI
involved in positive regulation of protein metabolic process IGI
IGI: 通过遗传相互作用推断
20164328 MGI
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
17898229 MGI
involved in regulation of amyloid fibril formation IGI
IGI: 通过遗传相互作用推断
20164328 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: 通过突变表型推断
12508119 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: 通过突变表型推断
9364063 MGI
acts upstream of or within regulation of norepinephrine secretion IMP
IMP: 通过突变表型推断
10942027 MGI
involved in regulation of synapse structural plasticity IMP
IMP: 通过突变表型推断
20164328 MGI
acts upstream of or within regulation of synaptic transmission, dopaminergic IMP
IMP: 通过突变表型推断
16772172 MGI
involved in response to amyloid-beta IMP
IMP: 通过突变表型推断
19118188 MGI
involved in response to cold IDA
IDA: 通过直接分析推断
19230830 MGI
acts upstream of or within response to ethanol IMP
IMP: 通过突变表型推断
15555774 MGI
acts upstream of or within response to food IMP
IMP: 通过突变表型推断
15922075 MGI
involved in response to nicotine IGI
IGI: 通过遗传相互作用推断
11404397 MGI
acts upstream of or within response to nicotine IMP
IMP: 通过突变表型推断
9495872 MGI
involved in sensory processing IDA
IDA: 通过直接分析推断
17898229 MGI
involved in synapse organization IGI
IGI: 通过遗传相互作用推断
19587288 MGI
involved in synaptic transmission, cholinergic IGI
IGI: 通过遗传相互作用推断
20164328 MGI
acts upstream of or within synaptic transmission, cholinergic IMP
IMP: 通过突变表型推断
9364063 MGI
acts upstream of tumor necrosis factor production IMP
IMP: 通过突变表型推断
12508119 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
16033766 MGI
located in axolemma IDA
IDA: 通过直接分析推断
18458158 MGI
is active in cholinergic synapse IDA
IDA: 通过直接分析推断
12079404 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
15963492 MGI
located in membrane IDA
IDA: 通过直接分析推断
11834293 MGI
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
24607281 MGI
is active in postsynaptic membrane IEP
IEP: 通过表达模式推断
24607281 MGI
is active in postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
12079404 MGI
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
24607281 MGI
is active in presynaptic membrane IEP
IEP: 通过表达模式推断
24607281 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neuronal acetylcholine receptor subunit alpha-7

acetylcholine receptor alpha 7 neural

alpha7 nicotinic receptor

alpha7-nAChR

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02672 CHRNA7 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS02659 CHRFAM7A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19768 Chrna7 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26265 Chrna7 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Chrna7 NCBI NCBI:1139
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