PKD1L2 - polycystin 1 like 2 (gene/pseudogene) Gene

中文名称：多囊蛋白 1 like 2 (基因/假基因)

种属: Homo sapiens

同用名: PC1L2

基因 ID: 114780 | 基因类型: protein coding

关于 PKD1L2

Cytogenetic location: 16q23.2 Genomic coordinates (GRCh38): 16:81,100,875-81,220,394 (from NCBI)

This gene has 11 transcripts (splice variants), 309 orthologues and 10 paralogues. Biased expression in fat (RPKM 3.7), heart (RPKM 1.2) and 7 other tissues.

功能概要

该基因编码多囊蛋白家族的一个成员。该蛋白可作为 G 蛋白偶联成分或阳离子通道孔调节剂发挥作用。这种蛋白质的长异构体包含 11 个跨膜结构域、一个 latrophilin/CL-1 样 GPCR 蛋白水解位点 (GPS) 结构域和一个多囊蛋白-1、脂氧合酶、α-毒素 (PLAT) 结构域。可变剪接导致编码不同异构体的多个转录变体。该基因是人类的多态性假基因。[RefSeq 提供，2022 年 5 月]

This gene encodes a member of the polycystin protein family. This protein may function as a G-protein-coupled component or regulator of cation channel pores. The long isoform of this protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, Lipoxygenase, alpha-toxin (PLAT) domain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene is a polymorphic pseudogene in humans. [provided by RefSeq, May 2022]

PKD1L2 基因产物(4)

mRNA	Protein	Name
NM_001076780.3	NP_001070248.2	polycystic kidney disease protein 1-like 2 isoform c precursor
NM_001278423.2	NP_001265352.1	polycystic kidney disease protein 1-like 2 isoform e
NM_001278425.3	NP_001265354.2	polycystic kidney disease protein 1-like 2 isoform d
NM_052892.5	NP_443124.4	polycystic kidney disease protein 1-like 2 isoform a precursor

蛋白主名

其他名称

polycystic kidney disease protein 1-like 2

PC1-like 2 protein

关联疾病

疾病名称

别名

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Kidney Disease

Renal Failure	Kidney Failure
Kidney Diseases	Nephropathy
Abnormality Of The Kidney	Impaired Renal Function Disease
Renal Anomaly	Kidney Dysfunction
Renal Disease	Nephropathies
Renal Failure Adverse Event	Abnormal Renal Function

Conduct Disorder

Macular Degeneration, Age-Related, 10

ARMD10	Age Related Macular Degeneration 10
Macular Degeneration, Age-Related, Type 10

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1	PKD1
Adpkd	Polycystic Kidney Disease, Adult, Type I
Apkd1	Potter Type Iii Polycystic Kidney Disease
Polycystic Kidney Disease, Adult	Potter Type Iii Polycystic Kidney Disease, Formerly
Polycystic Kidney Disease, Type 1	Adpkd1
Adult Polycystic Kidney Disease Type 1	Autosomal Dominant Polycystic Kidney Disease 1
Pkd-1	Polycystic Kidney Disease Adult
Polycystic Kidney Disease Type I	Polycystic Kidneys
Polycystic Kidney Disease, Adult Type I	Polycystic Kidney Type 1 Autosomal Dominant Disease
Kidney Disease, Polycystic, Type 1	Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Type 1 Autosomal Dominant Disease	Polycystic Kidney Diseases

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-15698	CRT0066101		99.66%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-13687	IKK 16	Inhibitor	99.88%	否
HY-15698A	CRT0066101 dihydrochloride		99.92%	否
HY-12239	CID755673	Inhibitor	99.13%	否
HY-13687A	IKK 16 hydrochloride	Inhibitor	99.95%	否
HY-118052	BPKDi	Inhibitor	99.60%	否
HY-15528	kb NB 142-70	Inhibitor	98.02%	否
HY-151374	3-IN-PP1	Inhibitor	99.58%	否
HY-112547	CRT5	Inhibitor	98.70%	否
HY-117051	STA-2842	Inhibitor	/	否
HY-15698B	CRT0066101 trihydrochloride		/	否
HY-RS00006	PKD1L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PKD1L2	RGD	RGD:1588631
Mus musculus	PKD1L2	MGD	MGI:2664668
Canis familiaris	PKD1L2	VGNC	VGNC:56013

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PKD1L2 - polycystin 1 like 2 (gene/pseudogene) Gene

关于 PKD1L2

功能概要

PKD1L2 基因产物(4)

关联疾病

直系同源

热门区域

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PKD1L2 - polycystin 1 like 2 (gene/pseudogene) Gene

关于 PKD1L2

功能概要

PKD1L2 基因产物(4)

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z