2. Gene
  3. Atp2a2 - ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Gene

Atp2a2 - ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: SERCA2; SERCA2B; Serca2a; D5Wsu150e; mKIAA4195; 9530097L16Rik

基因 ID: 11938 | 基因类型: protein coding

关于 Atp2a2

功能概要

Enables several functions, including P-type calcium transporter activity; calcium ion binding activity; and protein C-terminus binding activity. Acts upstream of or within several processes, including T-tubule organization; cardiac muscle hypertrophy in response to stress; and regulation of heart contraction. Located in endoplasmic reticulum membrane; ribbon synapse; and sarcoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Used to study keratosis follicularis. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp2a2 基因产物(2)

mRNA Protein Name
NM_001110140.3 NP_001103610.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b
NM_009722.3 NP_033852.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables P-type calcium transporter activity IDA
IDA: 通过直接分析推断
9887021 MGI
enables P-type calcium transporter activity IMP
IMP: 通过突变表型推断
29475982 MGI
enables enzyme binding IPI
IPI: 通过物理相互作用推断
21903937 MGI
enables lncRNA binding IPI
IPI: 通过物理相互作用推断
29475982 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14749390 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within ER-nucleus signaling pathway IMP
IMP: 通过突变表型推断
14561754 MGI
acts upstream of or within T-tubule organization IMP
IMP: 通过突变表型推断
22355118 MGI
involved in calcium ion import into sarcoplasmic reticulum IMP
IMP: 通过突变表型推断
29475982 MGI
involved in calcium ion transmembrane transport IMP
IMP: 通过突变表型推断
31819041 MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress IDA
IDA: 通过直接分析推断
24137001 MGI
acts upstream of or within cellular response to oxidative stress IGI
IGI: 通过遗传相互作用推断
25452428 MGI
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: 通过直接分析推断
9887021 MGI
acts upstream of or within intracellular calcium ion homeostasis IGI
IGI: 通过遗传相互作用推断
12756243 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: 通过突变表型推断
12756243 MGI
acts upstream of or within negative regulation of heart contraction IGI
IGI: 通过遗传相互作用推断
10555147 MGI
acts upstream of or within neuron cellular homeostasis IGI
IGI: 通过遗传相互作用推断
12756243 MGI
acts upstream of or within neuron cellular homeostasis IMP
IMP: 通过突变表型推断
12756243 MGI
acts upstream of or within organelle organization IMP
IMP: 通过突变表型推断
22355118 MGI
acts upstream of or within positive regulation of cardiac muscle cell apoptotic process IDA
IDA: 通过直接分析推断
31819041 MGI
acts upstream of or within positive regulation of endoplasmic reticulum calcium ion concentration IMP
IMP: 通过突变表型推断
30188326 MGI
acts upstream of or within regulation of calcium ion-dependent exocytosis of neurotransmitter IMP
IMP: 通过突变表型推断
21106823 MGI
acts upstream of or within regulation of the force of heart contraction IGI
IGI: 通过遗传相互作用推断
10555147 MGI
acts upstream of or within sarcoplasmic reticulum calcium ion transport IMP
IMP: 通过突变表型推断
22355118 MGI
acts upstream of or within transition between fast and slow fiber IDA
IDA: 通过直接分析推断
18978355 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
23395171 MGI
located in membrane IDA
IDA: 通过直接分析推断
16407245 MGI
located in ribbon synapse IDA
IDA: 通过直接分析推断
19932743 MGI
located in sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
9038922 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sarcoplasmic/endoplasmic reticulum calcium ATPase 2

SR Ca(2+)-ATPase 2

calcium pump 2

endoplasmic reticulum class 1/2 Ca(2+) ATPase

sarco/endoplasmic reticulum Ca2+-ATPase 2

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-15718A Istaroxime hydrochloride 99.32% Phase 2
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-131760 2'-NH2-ATP / 否
HY-RS01192 ATP2A2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01195 ATP2B2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01199 ATP2C2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17846 Atp2a2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24314 Atp2a2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atp2a2 NCBI NCBI:488
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