2. Gene
  3. Cask - calcium/calmodulin-dependent serine protein kinase (MAGUK family) Gene

Cask - calcium/calmodulin-dependent serine protein kinase (MAGUK family) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: LIN-2; Pals3; DXPri1; DXRib1; mLin-2

基因 ID: 12361 | 基因类型: protein coding

关于 Cask

功能概要

Enables neurexin family protein binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within calcium ion import; positive regulation of calcium ion import; and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including basolateral plasma membrane; cell-cell junction; and cytosol. Is active in Schaffer collateral - CA1 synapse. Colocalizes with basement membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/Calmodulin dependent serine protein kinase). [provided by Alliance of Genome Resources, Apr 2022]

Cask 基因产物(4)

mRNA Protein Name
NM_001284503.1 NP_001271432.1 peripheral plasma membrane protein CASK isoform 1
NM_001284504.1 NP_001271433.1 peripheral plasma membrane protein CASK isoform 2
NM_001284505.1 NP_001271434.1 peripheral plasma membrane protein CASK isoform 3
NM_009806.3 NP_033936.2 peripheral plasma membrane protein CASK isoform 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables neurexin family protein binding IDA
IDA: 通过直接分析推断
18054859 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12093160 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within calcium ion import IMP
IMP: 通过突变表型推断
18054859 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
18054859 MGI
acts upstream of or within positive regulation of calcium ion import IDA
IDA: 通过直接分析推断
18054859 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15584924 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: 通过直接分析推断
17287346 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: 通过突变表型推断
17287346 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
17287346 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
17287346 MGI
colocalizes with basement membrane IDA
IDA: 通过直接分析推断
18664494 MGI
located in basement membrane IDA
IDA: 通过直接分析推断
18664494 MGI
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
12351654 MGI
located in cell-cell junction IDA
IDA: 通过直接分析推断
18664494 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
18664494 MGI
located in cytosol IDA
IDA: 通过直接分析推断
12202822 MGI
located in membrane IDA
IDA: 通过直接分析推断
18054859 MGI
located in nucleus IDA
IDA: 通过直接分析推断
18664494 MGI
located in synapse IDA
IDA: 通过直接分析推断
12202822 MGI
located in vesicle IDA
IDA: 通过直接分析推断
19036990 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

peripheral plasma membrane protein CASK

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-115719 NR162 Inhibitor 99.7% 否
HY-RS01938 CASK Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18466 Cask Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24947 Cask Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cask NCBI NCBI:8573
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