2. Gene
  3. Cdkn1c - cyclin-dependent kinase inhibitor 1C (P57) Gene

Cdkn1c - cyclin-dependent kinase inhibitor 1C (P57) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CDKI; Kip2; p57Kip2; p57(kip2)

基因 ID: 12577 | 基因类型: protein coding

关于 Cdkn1c

功能概要

Predicted to enable protein kinase inhibitor activity. Involved in negative regulation of phosphorylation. Acts upstream of or within several processes, including animal organ development; genetic imprinting; and regulation of exit from Mitosis. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Used to study Beckwith-Wiedemann syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome; IMAGe syndrome; and hyperinsulinism. Orthologous to human CDKN1C (cyclin dependent kinase inhibitor 1C). [provided by Alliance of Genome Resources, Apr 2022]

Cdkn1c 基因产物(20)

mRNA Protein Name
NM_001161624.2 NP_001155096.1 cyclin-dependent kinase inhibitor 1C isoform 1
NM_001354981.2 NP_001341910.1 cyclin-dependent kinase inhibitor 1C isoform 2
NM_001412230.1 NP_001399159.1 cyclin-dependent kinase inhibitor 1C isoform 3
NM_001412231.1 NP_001399160.1 cyclin-dependent kinase inhibitor 1C isoform 3
NM_001412232.1 NP_001399161.1 cyclin-dependent kinase inhibitor 1C isoform 1
NM_001412233.1 NP_001399162.1 cyclin-dependent kinase inhibitor 1C isoform 4
NM_001412234.1 NP_001399163.1 cyclin-dependent kinase inhibitor 1C isoform 4
NM_001412235.1 NP_001399164.1 cyclin-dependent kinase inhibitor 1C isoform 4
NM_001412236.1 NP_001399165.1 cyclin-dependent kinase inhibitor 1C isoform 4
NM_001412237.1 NP_001399166.1 cyclin-dependent kinase inhibitor 1C isoform 2
NM_001412238.1 NP_001399167.1 cyclin-dependent kinase inhibitor 1C isoform 2
NM_001412239.1 NP_001399168.1 cyclin-dependent kinase inhibitor 1C isoform 5
NM_001412240.1 NP_001399169.1 cyclin-dependent kinase inhibitor 1C isoform 6
NM_001412241.1 NP_001399170.1 cyclin-dependent kinase inhibitor 1C isoform 6
NM_001412242.1 NP_001399171.1 cyclin-dependent kinase inhibitor 1C isoform 6
NM_001412243.1 NP_001399172.1 cyclin-dependent kinase inhibitor 1C isoform 7
NM_001412244.1 NP_001399173.1 cyclin-dependent kinase inhibitor 1C isoform 7
NM_001412245.1 NP_001399174.1 cyclin-dependent kinase inhibitor 1C isoform 7
NM_001412246.1 NP_001399175.1 cyclin-dependent kinase inhibitor 1C isoform 7
NM_009876.5 NP_034006.3 cyclin-dependent kinase inhibitor 1C isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14671317 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adrenal gland development IMP
IMP: 通过突变表型推断
19276117 MGI
acts upstream of or within camera-type eye development IMP
IMP: 通过突变表型推断
19276117 MGI
acts upstream of or within digestive system development IMP
IMP: 通过突变表型推断
19276117 MGI
acts upstream of or within embryonic placenta morphogenesis IMP
IMP: 通过突变表型推断
19276117 MGI
acts upstream of or within genomic imprinting IMP
IMP: 通过突变表型推断
19276117 MGI
acts upstream of or within kidney development IMP
IMP: 通过突变表型推断
19276117 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
19276117 MGI
acts upstream of or within myeloid cell differentiation IGI
IGI: 通过遗传相互作用推断
15889154 MGI
involved in negative regulation of phosphorylation IDA
IDA: 通过直接分析推断
19170105 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
14671317 MGI
acts upstream of or within neuron maturation IMP
IMP: 通过突变表型推断
14671317 MGI
acts upstream of or within placenta development IGI
IGI: 通过遗传相互作用推断
9784491 MGI
acts upstream of or within placenta development IMP
IMP: 通过突变表型推断
21729874 MGI
acts upstream of or within regulation of exit from mitosis IGI
IGI: 通过遗传相互作用推断
9784491 MGI
acts upstream of or within regulation of lens fiber cell differentiation IGI
IGI: 通过遗传相互作用推断
9784491 MGI
acts upstream of or within skeletal system development IMP
IMP: 通过突变表型推断
19276117 MGI
acts upstream of or within uterus development IMP
IMP: 通过突变表型推断
19276117 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
11737597 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cyclin-dependent kinase inhibitor 1C

cyclin-dependent kinase inhibitor p57

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02413 CDKN1C Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20537 Cdkn1c Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27046 Cdkn1c Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdkn1c NCBI NCBI:1028
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