2. Gene
  3. Cdkn2c - cyclin dependent kinase inhibitor 2C Gene

Cdkn2c - cyclin dependent kinase inhibitor 2C Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: p18; INK4c; p18-INK6; p18INK4c; p18-INK4c

基因 ID: 12580 | 基因类型: protein coding

关于 Cdkn2c

功能概要

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, and contains five ankyrin repeats. This protein interacts with both CDK4 and CDK6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]

Cdkn2c 基因产物(2)

mRNA Protein Name
NM_001301368.1 NP_001288297.1 cyclin-dependent kinase 4 inhibitor C
NM_007671.3 NP_031697.1 cyclin-dependent kinase 4 inhibitor C
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
IDA: 通过直接分析推断
7739547 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
7739547 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
17409423 MGI
acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
7739547 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: 通过遗传相互作用推断
17409423 MGI
acts upstream of stem cell proliferation IGI
IGI: 通过遗传相互作用推断
17409423 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cyclin-dependent kinase 4 inhibitor C

cyclin-dependent kinase 6 inhibitor

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02417 CDKN2C Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18854 Cdkn2c Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25346 Cdkn2c Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdkn2c NCBI NCBI:1031
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