2. Gene
  3. Dab2 - disabled 2, mitogen-responsive phosphoprotein Gene

Dab2 - disabled 2, mitogen-responsive phosphoprotein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: p96; Doc2; Doc-2; D15Wsu122e; 5730435J12Rik; D630005B22Rik

基因 ID: 13132 | 基因类型: protein coding

关于 Dab2

功能概要

Enables several functions, including AP-2 adaptor complex binding activity; clathrin adaptor activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within several processes, including endocytosis; hemopoiesis; and negative regulation of extrinsic apoptotic signaling pathway. Located in apical plasma membrane; cytoplasm; and nucleus. Part of clathrin coat of coated pit. Is expressed in several structures, including central nervous system; egg cylinder; embryo mesenchyme; future hindbrain roof plate; and metanephros. Orthologous to human DAB2 (DAB adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Dab2 基因产物(5)

mRNA Protein Name
NM_001008702.2 NP_001008702.1 disabled homolog 2 isoform b
NM_001037905.3 NP_001032994.1 disabled homolog 2 isoform b
NM_001102400.1 NP_001095870.1 disabled homolog 2 isoform c
NM_001310446.1 NP_001297375.1 disabled homolog 2 isoform d
NM_023118.5 NP_075607.2 disabled homolog 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables AP-2 adaptor complex binding IDA
IDA: 通过直接分析推断
12234931 MGI
enables cargo receptor activity IDA
IDA: 通过直接分析推断
16984970 MGI
enables clathrin adaptor activity IDA
IDA: 通过直接分析推断
16984970 MGI
enables clathrin binding IDA
IDA: 通过直接分析推断
12234931 MGI
enables integrin binding IMP
IMP: 通过突变表型推断
15734730 MGI
enables phosphatidylinositol binding IDA
IDA: 通过直接分析推断
12234931 MGI
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
12826668 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9569023 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell morphogenesis IMP
IMP: 通过突变表型推断
12413896 MGI
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: 通过直接分析推断
15734730 MGI
involved in clathrin coat assembly IDA
IDA: 通过直接分析推断
12234931 MGI
acts upstream of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
15734730 MGI
acts upstream of or within hematopoietic stem cell proliferation IDA
IDA: 通过直接分析推断
29925839 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
12413896 MGI
involved in myeloid cell differentiation IEP
IEP: 通过表达模式推断
11823414 MGI
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
15734730 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
15734730 MGI
involved in negative regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
19581412 MGI
involved in positive regulation of JNK cascade IDA
IDA: 通过直接分析推断
15894542 MGI
involved in positive regulation of cell adhesion IDA
IDA: 通过直接分析推断
11823414 MGI
involved in positive regulation of cell adhesion IMP
IMP: 通过突变表型推断
15734730 MGI
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
15894542 MGI
involved in positive regulation of clathrin-dependent endocytosis IDA
IDA: 通过直接分析推断
16984970 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
15734730 MGI
involved in positive regulation of integrin-mediated signaling pathway IMP
IMP: 通过突变表型推断
15734730 MGI
involved in positive regulation of receptor internalization IMP
IMP: 通过突变表型推断
23354168 MGI
involved in positive regulation of receptor recycling IMP
IMP: 通过突变表型推断
20881059 MGI
involved in positive regulation of substrate adhesion-dependent cell spreading IDA
IDA: 通过直接分析推断
11823414 MGI
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
15734730 MGI
involved in positive regulation of transcription elongation by RNA polymerase II IMP
IMP: 通过突变表型推断
15894542 MGI
acts upstream of or within receptor-mediated endocytosis IPI
IPI: 通过物理相互作用推断
12413896 MGI
acts upstream of or within renal protein absorption IMP
IMP: 通过突变表型推断
11927540 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
21146513 MGI
part of clathrin coat of coated pit IDA
IDA: 通过直接分析推断
11247302 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
21146513 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

disabled homolog 2

adaptor molecule disabled-2

differentially expressed in ovarian carcinoma 2

mitogen-responsive phosphoprotein

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03511 DAB2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS03512 DAB2IP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20265 Dab2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26773 Dab2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-112114 DTPA-DAB2 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dab2 NCBI NCBI:1601
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