2. Gene
  3. Tmc1 - transmembrane channel-like gene family 1 Gene

Tmc1 - transmembrane channel-like gene family 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: dn; Bth; CWEA1; TMC1ex1; Beethoven; 4933416G09Rik

基因 ID: 13409 | 基因类型: protein coding

关于 Tmc1

功能概要

Enables voltage-gated Calcium Channel activity. Contributes to mechanosensitive ion channel activity. Acts upstream of or within several processes, including auditory receptor cell development; detection of mechanical stimulus involved in sensory perception of sound; and vestibular reflex. Located in external side of plasma membrane and stereocilium tip. Is expressed in sensory organ and skeleton. Used to study autosomal dominant nonsyndromic deafness 36 and autosomal recessive nonsyndromic deafness 7. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Orthologous to human TMC1 (transmembrane channel like 1). [provided by Alliance of Genome Resources, Apr 2022]

Tmc1 基因产物(1)

mRNA Protein Name
NM_028953.2 NP_083229.1 transmembrane channel-like protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium channel activity IMP
IMP: 通过突变表型推断
23871232 MGI
contributes to mechanosensitive monoatomic ion channel activity IGI
IGI: 通过遗传相互作用推断
24981230 MGI
contributes to mechanosensitive monoatomic ion channel activity IMP
IMP: 通过突变表型推断
24981230 MGI
enables mechanosensitive monoatomic ion channel activity IMP
IMP: 通过突变表型推断
23871232 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
25114259 MGI
enables voltage-gated calcium channel activity IGI
IGI: 通过遗传相互作用推断
23871232 MGI
enables voltage-gated calcium channel activity IMP
IMP: 通过突变表型推断
23871232 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within auditory receptor cell development IMP
IMP: 通过突变表型推断
22105175 MGI
acts upstream of or within calcium ion transmembrane transport IGI
IGI: 通过遗传相互作用推断
23871232 MGI
acts upstream of or within calcium ion transmembrane transport IMP
IMP: 通过突变表型推断
23871232 MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound IGI
IGI: 通过遗传相互作用推断
22105175 MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound IMP
IMP: 通过突变表型推断
22105175 MGI
acts upstream of or within regulation of calcium ion transmembrane transport IGI
IGI: 通过遗传相互作用推断
24981230 MGI
acts upstream of or within regulation of calcium ion transmembrane transport IMP
IMP: 通过突变表型推断
24981230 MGI
acts upstream of or within vestibular reflex IGI
IGI: 通过遗传相互作用推断
22105175 MGI
acts upstream of or within vestibular reflex IMP
IMP: 通过突变表型推断
24981230 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
16455951 MGI
located in stereocilium IDA
IDA: 通过直接分析推断
38228630 MGI
located in stereocilium tip IDA
IDA: 通过直接分析推断
22105175 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transmembrane channel-like protein 1

deafness protein

transmembrane cochlear-expressed protein 1

transmembrane, cochlear expressed 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14621 TMC1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21445 Tmc1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27963 Tmc1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tmc1 NCBI NCBI:117531
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