Drd2 - dopamine receptor D2 Gene

中文名称：多巴胺受体 D2

种属: Mus musculus

同用名: D2R; Drd-2

关于 Drd2

功能概要

该基因编码的蛋白可启动 G 蛋白偶联受体活性；多巴胺结合活性；和多巴胺神经递质受体活性，通过 Gi/Go 耦合。参与透明体血管丛退化；先天免疫反应的负调节；和神经递质运输的调节。作用于多个过程的上游或内部，包括调节化学突触传递；神经系统发育；和离子传输的调节。位于多个细胞成分中，包括 GABA 能突触；树突;和多巴胺能突触。是突触后膜的组成部分。在谷氨酸能突触中活跃。是突触前膜的组成部分。以多种结构表达，包括消化系统；泌尿生殖系统；神经系统;呼吸系统;和感觉器官。用于研究帕金森病和原发性醛固酮增多症。该基因的人类直系同源物与多种疾病有关，包括终末期肾病；精神抑郁症；有先兆的偏头痛；肥胖;和 2 型糖尿病。与人类 DRD2（多巴胺受体 D2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled receptor activity; dopamine binding activity; and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in hyaloid vascular plexus regression; negative regulation of innate immune response; and regulation of neurotransmitter transport. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of ion transport. Located in several cellular components, including GABA-ergic synapse; dendrite; and dopaminergic synapse. Is integral component of postsynaptic membrane. Is active in glutamatergic synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Parkinson's disease and primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; mental depression; migraine with aura; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (Dopamine Receptor D2). [provided by Alliance of Genome Resources, Apr 2022]