2. Gene
  3. Drd5 - dopamine receptor D5 Gene

Drd5 - dopamine receptor D5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：多巴胺受体 D5

种属: Mus musculus

同用名: D5R; Drd-5; Drd1b; Gpcr1

基因 ID: 13492 | 基因类型: protein coding

关于 Drd5

Chromosome 5: 38,476,710-38,479,861 forward strand.GRCm39:CM000998.3

This gene has 1 transcript (splice variant), 190 orthologues, 32 paralogues and is associated with 12 phenotypes.

功能概要

该基因编码的蛋白可启动多巴胺神经递质受体活性，通过 Gs 耦合。在多个过程的上游或内部行动，包括学习；长期突触抑制；和调节血压。位于刷状缘膜。以多种结构表达，包括消化系统；中枢神经系统;眼睛;泌尿生殖系统；和淋巴系统腺体。该基因的人类直系同源物与注意缺陷多动障碍和眼睑痉挛有关。与人类 DRD5（多巴胺受体 D5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables dopamine neurotransmitter receptor activity, coupled via Gs. Acts upstream of or within several processes, including learning; long-term synaptic depression; and regulation of blood pressure. Located in brush border membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and blepharospasm. Orthologous to human DRD5 (Dopamine Receptor D5). [provided by Alliance of Genome Resources, Apr 2022]

Drd5 基因产物(1)

mRNA Protein Name
NM_013503.4 NP_038531.1 D(1B) dopamine receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables dopamine neurotransmitter receptor activity, coupled via Gs IDA
IDA: 通过直接分析推断
16962565 MGI
enables dopamine neurotransmitter receptor activity, coupled via Gs IMP
IMP: 通过突变表型推断
13679419 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
15598876 MGI
acts upstream of or within associative learning IMP
IMP: 通过突变表型推断
15696326 MGI
acts upstream of or within long-term synaptic depression IMP
IMP: 通过突变表型推断
13679419 MGI
acts upstream of or within mating behavior IMP
IMP: 通过突变表型推断
15696326 MGI
acts upstream of or within negative regulation of blood pressure IGI
IGI: 通过遗传相互作用推断
12486173 MGI
acts upstream of or within negative regulation of blood pressure IMP
IMP: 通过突变表型推断
12486173 MGI
acts upstream of or within norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IMP
IMP: 通过突变表型推断
12486173 MGI
acts upstream of or within regulation of female receptivity IMP
IMP: 通过突变表型推断
15696326 MGI
acts upstream of or within regulation of systemic arterial blood pressure by vasopressin IGI
IGI: 通过遗传相互作用推断
12486173 MGI
acts upstream of or within response to amphetamine IGI
IGI: 通过遗传相互作用推断
11823893 MGI
acts upstream of or within response to cocaine IMP
IMP: 通过突变表型推断
12768268 MGI
acts upstream of or within sensitization IGI
IGI: 通过遗传相互作用推断
11823893 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: 通过突变表型推断
12867509 MGI
acts upstream of or within wound healing IMP
IMP: 通过突变表型推断
11595429 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in brush border membrane IDA
IDA: 通过直接分析推断
15598876 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Drd5 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (38 - 363)

7tm_GPCRs

7tm_GPCRs: cd14964 (40 - 64)

7tm_GPCRs

7tm_GPCRs: cd14964 (74 - 96)

7tm_GPCRs

7tm_GPCRs: cd14964 (111 - 133)

7tm_GPCRs

7tm_GPCRs: cd14964 (156 - 172)

7tm_GPCRs

7tm_GPCRs: cd14964 (216 - 239)

7tm_GPCRs

7tm_GPCRs: cd14964 (288 - 310)

7tm_GPCRs

7tm_GPCRs: cd14964 (332 - 357)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 478 a.a.
蛋白主名 其他名称

D(1B) dopamine receptor

d(5) dopamine receptor

dopamine D5 receptor

dopamine receptor 5

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04006 DRD5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS04007 Drd5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS04008 Drd5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Drd5 NCBI NCBI:1816
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